Chilblain ointment formula and preparation method thereof

A chilblain and formula technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, ointment delivery, etc., can solve the problems of inability to relieve patients' discomfort, poor antipruritic effect, and long treatment cycle, so as to improve the absorption effect of medicine , Suppress itching and shorten the treatment cycle

Pending Publication Date: 2021-09-14
BEIJING SHENGYONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the existing chilblain ointments can only act on the skin surface, and the drug absorption is poor, resulting in a longer treatment cycle. At the same time, the patient often has unbearable itching in the affected part during the scabbing process of chilblain, while the existing chilblain ointment relieves itching. The effect is poor, can not relieve the patient's discomfort

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] The preparation method of described antipruritic is:

[0058] Take by weighing 4 parts of Fructus Cnidii, 4 parts of Sophora flavescens, 2 parts of hibiscus bark, 1 part of menthol, and 30 parts of 75% ethanol solution;

[0059] Grind cnidium fruit, flavescens, and hibiscus bark into coarse powder and mix;

[0060] Soak the mixed coarse powder in 10 parts of ethanol solution and let it stand for 4-8 hours;

[0061] After standing still, the remaining ethanol solution is added to the standing liquid by percolation step-by-step addition method to obtain tincture;

[0062] Add menthol to the tincture for an anti-itch remedy.

[0063] Among them, Fructus Cnidii has the effect of drying dampness, killing insects and relieving itching; Sophora flavescens is mainly used for dysentery, blood in the stool, jaundice and urinary retention, red and white vaginal discharge, swollen and itchy vulva, eczema, eczema, itchy skin, scabies Ringworm, leprosy, etc.; have the effects of e...

Embodiment 1

[0079] Step 1: Weigh grass safflower, hawthorn, cork, mirabilite, orange peel, comfrey, rehmannia glutinosa, red pepper according to the ratio of 6:13:5:4:18:5:6:7, dry and pulverize, and mix the powder evenly;

[0080] Step 2: Mix the mixed powder obtained in Step 1 with the ethanol solution at a mass ratio of 1:6, perform supercritical carbon dioxide extraction, collect the extract, distill and recover ethanol, and collect the residue;

[0081] Step 3: After washing the residue with deionized water, dry it;

[0082] Step 4: Evaporate and concentrate the extract to 1 / 3 of the original volume;

[0083] Step 5: Mix and stir the residue after drying with the concentrated extract at a mass ratio of 3:1 until it becomes a paste to obtain a traditional Chinese medicine ointment;

[0084] Step 6: Take the antipruritic agent, traditional Chinese medicine ointment and emu oil according to the mass ratio of 2:18:80, mix them evenly and then sterilize to obtain chilblain ointment, whe...

Embodiment 2

[0086] The difference between this embodiment and Example 1 is that the formula of the antipruritic agent is Mituseng, Baiji, light powder, and Kuluman.

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PUM

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Abstract

The invention discloses a chilblain ointment formula and a preparation method thereof; on one hand, the chilblain ointment formula provided by the invention is composed of the following components: an antipruritic, a traditional Chinese medicine ointment and emu oil; the traditional Chinese medicine ointment comprises the following components: safflower, hawthorn, golden cypress, mirabilite, orange peel, lithospermum, prepared rehmannia root and red pepper, wherein the ratio of the safflower to the hawthorn to the golden cypress to the mirabilite to the orange peel to the lithospermum to the prepared rehmannia root to the red pepper is (5-10):(8-16):(3-8):(2-6):(10-20):(3-5):(4-7):(3-10); the chilblain ointment formula is prepared from the following components in percentage by mass: 0.1-5% of the antipruritic, 10-30% of the traditional Chinese medicine ointment and the balance of the emu oil; according to the invention, various traditional Chinese medicine components are added in the formula; the chilblain ointment has a good treatment effect on chilblain; meanwhile, the emu oil serves as a matrix of the chilblain ointment; the medicine effect absorption effect of the chilblain ointment is greatly improved; and the chilblain treatment cycle is obviously shortened.

Description

technical field [0001] The invention relates to a chilblain ointment, in particular to a chilblain ointment formula and a preparation method thereof. Background technique [0002] Frostbite is common in winter. Due to the repeated erythema and swelling damage of the local skin caused by the cold climate, blisters and ulcers may appear in severe cases. The course of the disease is slow. Cold is the main cause of frostbite. The cause of the disease is that when the skin of chilblain patients encounters cold (0-10°C), humidity, or sudden changes in temperature, the local arterioles shrink, and over time the arteries become paralyzed and dilated, the veins are congested, and the local blood circulation is poor. The patient's own skin moisture, peripheral microvascular malformations, autonomic nervous dysfunction, malnutrition, endocrine disorders and other factors may also participate in the pathogenesis. In addition, factors such as lack of exercise, sweaty hands and feet, ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/81A61K36/898A61K47/44A61P17/02A61P17/04A61K33/04A61K31/045A61K33/241A61K33/28A61K33/06
CPCA61K9/06A61K9/0014A61K36/286A61K36/734A61K36/756A61K33/04A61K36/752A61K36/30A61K36/804A61K36/81A61K36/234A61K36/489A61K36/15A61K31/045A61K33/241A61K36/898A61K33/28A61K33/06A61K47/44A61P17/02A61P17/04A61K2236/37A61K2236/51A61K2300/00
Inventor 桑苏君
Owner BEIJING SHENGYONG PHARMA
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