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A kind of foot-and-mouth disease virus antibody, nucleic acid encoding it and application

A foot-and-mouth disease virus and antibody technology, which is applied in the field of foot-and-mouth disease virus antibody and foot-and-mouth disease virus, can solve problems such as limited research

Active Publication Date: 2022-05-17
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Neutralizing antibodies derived from natural hosts, the antigenic epitopes recognized by neutralizing antibodies, and the neutralization mechanism mediated by neutralizing antibodies are very limited

Method used

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  • A kind of foot-and-mouth disease virus antibody, nucleic acid encoding it and application
  • A kind of foot-and-mouth disease virus antibody, nucleic acid encoding it and application
  • A kind of foot-and-mouth disease virus antibody, nucleic acid encoding it and application

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Embodiment Construction

[0047] The above content of the present invention will be further described in detail in the form of preferred implementation examples below, but it does not constitute a limitation to the present invention.

[0048] Unless otherwise specified, the reagents in the examples of the present invention can be purchased through commercial channels.

[0049] 1. Virus strains, cells and reagents

[0050] FMD virus strain FMDV A / WH / CHA / 09 belongs to serotype A Asia topological type SEA-97 / G1.

[0051] The FMD virus strain FMDV A / GDMM / CHA / 2013 belongs to serotype A Asia topology SEA-97 / G2.

[0052] The foot-and-mouth disease virus strain FMDV O / Mya / 98 belongs to the serotype O SEA topology.

[0053] Foot-and-mouth disease virus strain FMDV O / Tibet / 99 belongs to serotype O ME-SA topology.

[0054] The pcDNA3.4 expression vector was purchased from Thermo Scientific, USA.

[0055] CHO-S cells and BHK21 cells were purchased from Gibco.

[0056] Metal carrier grid (GIG, Au 1.2 / 1.3, 200 ...

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Abstract

The invention relates to a foot-and-mouth disease virus antibody, nucleic acid encoding it and application. The foot-and-mouth disease virus antibody includes a heavy chain and a light chain, wherein the amino acid sequence of the heavy chain is shown in SEQ ID No.1, and the amino acid sequence of the light chain is shown in SEQ ID No.2. This is the first time that the neutralization mechanism of the FMD virus antibody is found by enhancing the stability of the FMD virus capsid to neutralize the FMD virus infection.

Description

technical field [0001] The invention relates to the field of foot-and-mouth disease virus, in particular to the field of foot-and-mouth disease virus antibody. Background technique [0002] Foot-and-mouth disease (FMD) is an acute and highly contagious infectious disease that seriously harms cloven-hoofed animals such as pigs, cattle and sheep, and causes huge losses to my country's animal husbandry industry every year. ) and the Food and Agriculture Organization of the United Nations (FAO) are classified as Class A severe infectious diseases, and my country classifies it as Class I animal infectious diseases. [0003] Foot-and-mouth disease is caused by foot-and-mouth disease virus, which belongs to the foot-and-mouth disease virus genus of the picornaviridae family. There are currently seven different serotypes in the world, which are O, A, C, Asia I (Asia1), South Africa I (SAT1), South Africa II (SAT2) and South Africa III (SAT3). ), each of which can be divided into ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/10C12N15/13C12N5/10C07K14/09A61K39/395A61K48/00A61K35/54A61P31/14
CPCC07K16/1009C07K14/09A61K48/005A61K35/54A61P31/14C07K2317/51C07K2317/515A61K2039/5258A61K2039/552A61K2039/505Y02A40/70
Inventor 何勇李坤娄智勇杨诚
Owner NANKAI UNIV
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