Application of patchoulenone in preparation of MCR-1 enzyme inhibitor

Abstract

The invention relates to application of patchoulenone in preparation of an MCR-1 enzyme inhibitor, the survival rates of a patchoulenone group in corresponding time are 66.7%, 41.7% and 8.3%, and the survival rates of mice in a patchoulenone and polymyxin E group in corresponding time are 83.3%, 75.0% and 41.7% respectively. Results show that the death rate of mice is remarkably reduced after treatment with the combination of the patchoulenone and the polymyxin E, a single treatment group of the patchoulenone or the polymyxin E does not have a remarkable effect, and the patchoulenone can improve the treatment effect of the polymyxin E.

Description

technical field [0001] The invention relates to the medical use of patchoulione in the preparation of MCR-1 enzyme inhibitors, and belongs to the technical field of medicine and pharmacy. Background technique [0002] The irrational use of antibiotics exerts strong selection pressure on bacteria, making the problem of bacterial resistance to antibiotics increasingly serious. In particular, the infection caused by colistin-resistant Gram-negative bacteria has caused a great threat to the animal husbandry industry and has attracted more and more attention. Colistin antibiotics are the last line of defense in the treatment of multidrug-resistant Gram-negative bacterial infections. If the last line of defense in the treatment of bacterial infections is also broken by bacteria, human beings may enter the pre-antibiotic era. However, with the increasing use of colistin in clinical, animal husbandry and agriculture and the occurrence of some antibiotic abuse, the therapeutic effec...

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