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Application and products of cftr-dvl2-β-catenin pathway in leukemia

A leukemia and product technology, applied in the field of bioengineering, can solve problems such as detection differences, achieve high significance and ensure detection accuracy.

Active Publication Date: 2022-05-31
THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the current inspection methods require rich clinical experience and training, which can easily cause differences in detection from person to person. Therefore, it is necessary to develop leukemia detection methods at the molecular level, which will greatly improve the accuracy and ease of detection. important

Method used

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  • Application and products of cftr-dvl2-β-catenin pathway in leukemia
  • Application and products of cftr-dvl2-β-catenin pathway in leukemia
  • Application and products of cftr-dvl2-β-catenin pathway in leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

The application of the path in the preparation of products for leukemia detection.

[0033] Among them, leukemia includes B-cell acute lymphoblastic leukemia and T-cell acute lymphoblastic leukemia.

[0034] The detection is performed on a biological sample of the subject, and the biological sample is selected from peripheral blood.

Embodiment 2

Embodiment 1-2

[0052] E. Expression measurement: real-time fluorescence quantitative PCR system (7500 real-time PCR system, Applied

[0054] The amplification procedure is: pre-denaturation at 95°C for 2 minutes, denaturation at 95°C for 10 seconds, annealing at 60°C, extension at 72°C for 15 seconds

[0055] F. Determination: The expression level of β-actin gene was used as a positive control, and the quantitative data were expressed as mean ± standard deviation (SD),

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Abstract

The invention discloses the application and product of the CFTR-Dvl2-β-catenin pathway in leukemia, and belongs to the technical field of bioengineering. The CFTR‑Dvl2‑β‑catenin pathway has a significant high expression pattern in the blood cells of leukemia patients, which is detected by quantitative PCR. In the detection of leukemia, the application and products of the CFTR‑Dvl2‑β‑catenin pathway in leukemia are proposed, which have high significance and better guarantee of detection accuracy, and provide a theoretical basis and reference for clinical research.

Description

Application and products of CFTR-Dvl2-β-catenin pathway in leukemia technical field The present invention relates to the application and product of CFTR-Dv12-β-catenin approach, relate in particular to CFTR-Dv12-β- The application and product of catenin pathway in leukemia detection belong to the field of bioengineering technology. Background technique [0002] Leukemia is a class of malignant clonal diseases of hematopoietic stem cells. Clonal leukemia cells proliferate out of control, divide Mechanisms such as dysplasia and apoptosis are accumulated in the bone marrow and other hematopoietic tissues, and infiltrate other non-hematopoietic tissues. and organs, while inhibiting normal hematopoiesis. At present, the inspection items of leukemia include: six tests of blood biochemistry, blood routine, myeloproliferative degree and bone marrow Image analysis, from the perspective of inspection methods, is mainly based on the number, morphology and biochemical indicator...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158
Inventor 孙华钦刘燕燕林子媛
Owner THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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