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Compositions and methods for inhibiting post-surgical adhesions

A composition and preparation technology, which can be applied in the directions of drug combinations, surgical drugs, medical preparations of inactive ingredients, etc., can solve problems such as limiting therapeutic efficacy and the like

Pending Publication Date: 2021-10-15
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, these barriers do not always remain in place postoperatively, thus limiting their therapeutic efficacy

Method used

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  • Compositions and methods for inhibiting post-surgical adhesions
  • Compositions and methods for inhibiting post-surgical adhesions
  • Compositions and methods for inhibiting post-surgical adhesions

Examples

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example 1

[0262] Example 1 - Composite Membrane for Inhibiting Postoperative Adhesions

[0263] Here, we report the development of a biotargeted, photocrosslinkable nanopatch (pCNP) for the prevention of postoperative adhesions. pCNP is composed of two kinds of NPs. The first NP (NP-A) is designed to carry anti-inflammatory cargo and specifically bind to the injured site. Since the hallmark of an injured epithelial / mesothelial surface is exposed basement membrane, and a component of basement membrane is collagen type IV, we chose to target NP-A to collagen type IV. The second NP (NP-B) was designed to have a positively charged surface, opposite to the NP-A surface, to enable adsorption on the NP-A layer through ionic interactions ( Figure 1A ). The two NPs can then be cross-linked through the diaziridine reactive groups by UV irradiation to form nanopatches. pCNP is designed for sequential intraperitoneal administration ( Figure 1B ). First, the NP-A suspension is incubated at t...

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Abstract

In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Description

[0001] Government interests [0002] This invention was made with government support under Grant Nos. CA058223, CA178748, and CA150391 awarded by the National Institutes of Health. The government has certain rights in this invention. [0003] Cross References to Related Applications [0004] This application claims the benefit of U.S. Provisional Application No. 62 / 802,033, filed February 6, 2019, which is hereby incorporated by reference in its entirety for all purposes. [0005] References to Sequence Listings Submitted as Text Files via EFS WEB [0006] The sequence listing written in file 035052-542267_ST25.txt is 491 bytes, was created on February 4, 2020, and is hereby incorporated by reference. technical field [0007] The present invention relates to compositions and methods for inhibiting the formation of postoperative adhesions, and in particular, to particulate compositions that form composite films for inhibiting the formation of postoperative adhesions. ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/34A61K45/00A61P41/00
CPCA61K9/5146A61K9/5153A61K45/00A61P41/00A61L31/129A61L31/16A61L31/148A61L2300/43A61L2400/12A61K31/573A61L2430/40C08L67/04C08L79/02A61K2300/00A61K9/51B82Y5/00
Inventor 安德鲁·旺宓雨
Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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