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A pretreatment device and method for ic-icp-ms blood arsenic speciation analysis

An IC-ICP-MS, blood arsenic speciation technology, applied in measurement devices, analytical materials, material separation, etc., can solve the problems of low separation efficiency, long separation time, etc., to achieve a simple pretreatment process, reduce complexity, and ensure The effect of stability

Active Publication Date: 2022-05-31
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Paper-based passive filtration absorbs the solution through capillary action and traps the complex matrix in the microporous structure of the paper to achieve the effect of matrix separation, but this method often takes a long time to separate and the separation efficiency is low
Paper-based electrospray can solve this problem, but it needs to achieve atomization separation by applying a potential of several thousand volts. Therefore, how to conveniently and efficiently separate the interference of complex matrix has always been the prerequisite for accurate analysis of arsenic speciation in blood samples.

Method used

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  • A pretreatment device and method for ic-icp-ms blood arsenic speciation analysis
  • A pretreatment device and method for ic-icp-ms blood arsenic speciation analysis
  • A pretreatment device and method for ic-icp-ms blood arsenic speciation analysis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The arsenic-containing solution was injected into the IC-ICPMS system for speciation analysis.

[0080] In the step 1, the time for the finger to turn the fidget spinner 6 to make it rotate to a natural stop is 4-6 s.

[0081] In the step 2, the atomization time is 2 to 3 min, and the volume of the arsenic-containing solution is >100 μL.

[0082] In the step 3, a 100 μL flat-tip chromatographic injection needle was used for injection.

Embodiment 2

[0092] The arsenic-containing solution was injected into an IC-ICP-MS system for speciation analysis.

[0095] In the step 1, the time for the finger to move the fidget spinner 6 to make it rotate to a natural stop is 4-6 s.

[0096] In the step 2, the atomization time is 2 to 3 min, and the volume of the arsenic-containing solution is >100 μL.

[0097] In the step 3, a 100 μL flat-tip chromatographic injection needle was used for injection.

Embodiment 3

[0106] The arsenic-containing solution was injected into the IC-ICPMS system for speciation analysis.

[0109] In the step 1, the time for the finger to turn the fidget spinner 6 to make it rotate to a natural stop is 4-6 s.

[0110] In the step 2, the atomization time is 2 to 3 min, and the volume of the arsenic-containing solution is >100 μL.

[0111] In the step 3, a 100 μL flat-tip chromatography injection needle was used for injection.

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Abstract

An IC‑ICP‑MS blood arsenic speciation analysis pretreatment device and method, belonging to the field of blood arsenic speciation analysis, the device includes a magnetic-assisted dispersive extraction system and an ultrasonic atomization separation system; the magnetic-assisted dispersive extraction system includes a fidget spinner, a rotating shaft , 4 circular magnets, 2 rectangular parallelepiped magnets Ⅰ, 2 rectangular parallelepiped magnets Ⅱ, centrifuge tube, magnetic stirrer and base; the middle section of the centrifuge tube is equipped with an ultrasonic atomization separation system. The device of the present invention extracts and separates blood arsenic, and the resulting solution can be directly used for subsequent IC-ICP MS analysis, which not only makes the pretreatment process simple and fast, ensures the stability of the arsenic form, but also efficiently extracts blood Medium arsenic, under optimized conditions, the extraction efficiency of blood arsenic is >96%, and the recovery rate of standard addition is 96-103%. The invention lays a foundation for the miniaturization and on-line of sample pretreatment of complex matrix.

Description

A kind of IC-ICP-MS blood arsenic speciation analysis pretreatment device and method technical field The invention belongs to the field of blood arsenic speciation analysis, particularly a kind of magnetic collection-assisted dispersion extraction and ultrasonic spray analysis. An all-in-one pretreatment device and method for the analysis of arsenic speciation in blood by IC‑ICP‑MS. Background technique Arsenic is a widely distributed and bioaccumulative metalloid element, mainly through food and drinking water. Once ingested, soluble arsenic readily enters the bloodstream from the gastrointestinal tract and is distributed to organs after the first passage through the liver officer / organization. Long-term exposure to arsenic can lead to a range of health problems, such as kidney cancer, skin cancer, peripheral neuropathy and cardiovascular disease disease, etc. Understanding arsenic species in blood is useful for identifying and quantifying arsenic exposure in orga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/96
CPCG01N30/06G01N30/96Y02P10/20
Inventor 于永亮张晓刘双王建华
Owner NORTHEASTERN UNIV LIAONING