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A compound traditional Chinese medicine preparation, preparation method and application for preventing and treating prophylactic algal mastitis

A technology of compound Chinese medicine and mastitis, which is applied in the field of compound Chinese medicine preparation, preparation, and prevention and treatment of Prototheca dairy cattle mastitis, which can solve the problem of difficult cure of dairy cows, affect the economic benefits of dairy farms, and threaten the quality and safety of fresh milk and public health safety and other issues, to achieve the effect of infection control, quality improvement and reasonable price

Active Publication Date: 2022-07-01
WUHAN ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The study further found that most bovine Prototheca are highly transmissible and insensitive to most antibiotics and antifungals. Once infection occurs in dairy cows, it is difficult to cure, which greatly affects the economic benefits of dairy farms and further threatens the quality and safety of raw milk and public health safety

Method used

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  • A compound traditional Chinese medicine preparation, preparation method and application for preventing and treating prophylactic algal mastitis
  • A compound traditional Chinese medicine preparation, preparation method and application for preventing and treating prophylactic algal mastitis
  • A compound traditional Chinese medicine preparation, preparation method and application for preventing and treating prophylactic algal mastitis

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preparation example Construction

[0030] The invention discloses a compound traditional Chinese medicine preparation, preparation method and application for preventing and treating Prototheca mastitis in dairy cows, as shown in the following examples. The compound traditional Chinese medicine preparation involved in the present invention comprises: 40-50 parts of Rhizoma chinensis, 30-40 parts of Sophora flavescens, 10-20 parts of Baiji, 1-2 parts of Chinese prickly ash, and 1-2 parts of borneol. Preferably, it is: 50 parts of Phellodendron chinensis, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Chinese prickly ash, and 1 part of borneol. The compound traditional Chinese medicine preparation prepared by the application is as follows: figure 1 shown.

[0031] Part of Prototheca bovis involved in this application includes the medium-sized Prototheca with the deposit numbers of CCTCC NO:M 2019978, CCTCC NO:M 2019979 and CCTCC NO:M 2019980 respectively, wherein the deposit number is the medium-siz...

Embodiment 1

[0033] Take 50 parts of Cortex Phellodendri, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Chinese prickly ash, 1 part of borneol (separately processed), a total of 1kg, add ten times of water to cook, boil with high heat and simmer for 60 minutes, filter out the medicine After slag, the medicinal liquid was concentrated to 1L, and ethanol was added to alcohol precipitation according to the final concentration of 75-80%. After 24 hours, the supernatant was taken for rotary evaporation, and the ethanol was recovered to obtain the compound traditional Chinese medicine extract; the weighed borneol was dissolved in a small amount of Hydroethanol and Tween-80 and other co-solvents are added to the compound traditional Chinese medicine extract, and finally the concentration of the compound extract is equivalent to the crude drug concentration of 1.0g / mL.

[0034] The pathogenic microorganisms Prototheca bovis strain 1 (1501#, PBHuB005, CCTCC M 2019979), Candida rugosa ...

Embodiment 2

[0042] Take 50 parts of Cortex Phellodendri, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Chinese prickly ash, 1 part of borneol (separately processed), a total of 1kg, add ten times of water to cook, boil with high heat and simmer for 60 minutes, filter out the medicine After slag, the medicinal liquid was concentrated to 1L, and ethanol was added to alcohol precipitation according to the final concentration of 75-80%. After 24 hours, the supernatant was taken for rotary evaporation, and the ethanol was recovered to obtain the compound traditional Chinese medicine extract; the weighed borneol was dissolved in a small amount of Hydroethanol and Tween-80 and other co-solvents are added to the compound traditional Chinese medicine extract, diluted with normal saline at 1:8 and sterilized to make compound traditional Chinese medicine mammary gland perfusion solution.

[0043] 3 cows with mastitis were used continuously for 5 days, once a day in the morning and even...

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Abstract

The invention belongs to the technical field of disease prevention and control in aquaculture, and in particular relates to a compound traditional Chinese medicine preparation, a preparation method and an application for preventing and treating Prototheca dairy cow mastitis. In the invention, traditional Chinese medicines such as Phellodendron chinensis, Sophora flavescens and the like are used for formulating and extracting through a certain process to prepare a compound traditional Chinese medicine mammary gland perfusion solution for preventing and treating achloroalgae mastitis, which is beneficial to the clinical treatment of achloroalgae mastitis. prevention and treatment. The present invention can effectively relieve the clinical symptoms of Prototheca bovine mastitis through mammary gland perfusion, reduce the infection amount of Prototheca bovis in the milk pond, has the functions of clearing heat and detoxification, reducing swelling and relieving pain, effectively controlling the infection of Prototheca bovis, and the price is reasonable. Etc.

Description

technical field [0001] The invention belongs to the technical field of disease prevention and control in aquaculture, and in particular relates to a compound traditional Chinese medicine preparation, a preparation method and an application for preventing and treating Prototheca dairy cow mastitis. Background technique [0002] Dairy cow mastitis is a common disease that endangers lactating dairy cows, which can cause the decline of milk production and fresh milk quality of dairy cows, cause certain economic losses, and threaten public health safety to a certain extent. The etiology of dairy cow mastitis is complex and diverse, and pathogenic microorganism infection is one of the most difficult to control aspects of many pathogenic factors. Over the past decade, dairy mastitis caused by Prototheca bovis has been on the rise worldwide (Ahrholdt et al 2011, Park et al 2019). The pathogenic microorganism is a green algae with a diameter of 7 to 30 μm. It was once called "medium...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P15/14A61P31/04A61P31/10A61K31/045
CPCA61K36/756A61K36/489A61K36/898A61K36/758A61K31/045A61K9/0041A61P15/14A61P31/04A61P31/10A61K2236/331A61K2236/333A61K2300/00
Inventor 陈洁邵志勇陈科力许顺鑫万平民金尔光陈夏冰陶利文谭珺隽刘晓华华娟
Owner WUHAN ACADEMY OF AGRI SCI
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