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Anti-BASIGIN humanized antibody and application thereof

A humanized antibody, technology in the sequence list, applied in the direction of antibody, application, anti-animal/human immunoglobulin, etc., can solve problems such as allergic and toxic reactions, blocking antibodies, etc.

Active Publication Date: 2021-10-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the repeated injection of mouse McAb into the human body will cause the patient to induce human anti mouse antibody (human anti mouse antibody, HAMA) reaction, cause systemic allergic toxicity and block the efficacy of the antibody

Method used

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  • Anti-BASIGIN humanized antibody and application thereof
  • Anti-BASIGIN humanized antibody and application thereof
  • Anti-BASIGIN humanized antibody and application thereof

Examples

Experimental program
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Embodiment Construction

[0036] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0037] 1. Terminology Explanation:

[0038]Immunoglobulin refers to a class of structurally related glycoproteins consisting of two pairs of polypeptide chains, a pair of low molecular weight light chains (L) and a pair of high molecular weight heavy chains (H), all four chains passing through Disulfide bonds link each other. Each heavy chain typically consists of a heavy chain variable region (abbreviated herein as VH) and a heavy chain constant region (abbreviated herein as CH). Each light chain typically consists of a light chain variable region (abbreviated herein as VL) and a light chain constant region (abbreviated herein as CL). The light chain constant region typically consists of one domain, CL. VH and VL can be further subdivided into hypervariable regions (or hypervariable hypervariable regions in sequence and / or in the form of ...

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PUM

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Abstract

The invention discloses an anti-BASIGIN humanized antibody and application thereof. The antibody comprises an immunoglobulin light chain variable region and an immunoglobulin heavy chain variable region; the immunoglobulin light chain variable region comprises CDR1 as shown in SEQ ID NO: 13 in a sequence table, cDR2 as shown in SEQ ID NO: 14 in the sequence table, and cDR3 as shown in SEQ ID NO: 15 in the sequence table; and the immunoglobulin heavy chain variable region comprises CDR1 as shown in SEQ ID NO: 16 in the sequence table, cDR2 as shown in SEQ ID NO: 17 in the sequence table, and cDR3 as shown in SEQ ID NO: 18 in the sequence table. The invention also discloses an application of the anti-BASIGIN humanized antibody in preparation of drugs for treating diseases related to anti-CD147 expression.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular, the invention provides an anti-BASIGIN humanized antibody and its application. Background technique [0002] BASIGIN (EMMPRIN, Neurothelin, M6 antigen, BASIGIN) is a highly glycosylated, transmembrane glycoprotein with a molecular weight of 50-60kD, which is a member of the immunoglobulin superfamily (IgSF). In humans, BASIGIN consists of 269 amino acids, which can be divided into extracellular region, transmembrane region and intracellular region. The first 21 residues after N-terminal translation are signal peptides, 22-205 constitute the extracellular region, 206-229 are transmembrane regions with a typical leucine zipper structure, and C-terminal 230-269 is the intracellular region. BASIGIN has been shown to be overexpressed in many types of human solid tumors, such as lung, liver, cervical, colon, breast, ovarian, esophageal or gastric cancer. [0003] Previous studies have show...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28C12N15/13C12N15/85A61K39/395A61P35/00A61P19/02A61P29/00
CPCC07K16/28C12N15/85A61K39/395A61P35/00A61P19/02A61P29/00A61K2039/505C12N2800/107C07K2317/24C07K2317/565C07K2317/92C07K2317/33C07K2317/56Y02A50/30
Inventor 陈志南朱平边惠洁张征南刚耿杰杰孙秀璇朱昱蒙王彬翟月郭婷
Owner FOURTH MILITARY MEDICAL UNIVERSITY