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Thaflavin composition for promoting wound healing as well as preparation method and application thereof

A technology of wound healing and theaflavin, applied in the field of medicine, can solve the problem that theaflavin is not well utilized, and achieve the effect of promoting wound healing, accelerating differentiation and blood vessel formation, and reducing infiltration

Active Publication Date: 2021-11-02
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the embodiments of the present invention is to provide several theaflavin compositions that promote wound healing, aiming to solve the problem that theaflavins are not well utilized in the pharmaceutical application in the prior art

Method used

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  • Thaflavin composition for promoting wound healing as well as preparation method and application thereof
  • Thaflavin composition for promoting wound healing as well as preparation method and application thereof
  • Thaflavin composition for promoting wound healing as well as preparation method and application thereof

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Embodiment 1

[0039] The embodiment of the present invention provides a theaflavin composition 1 for promoting wound healing, the main components of which include theaflavin-3-3'-digallate monomer, sodium acetate, chitosan, gelatin, glycerin, Propylene glycol, triethanolamine, and carbomer 940, between theaflavin-3-3'-digallate monomer, sodium acetate, chitosan, gelatin, glycerin, propylene glycol, triethanolamine, and carbomer 940 The mass ratio is 10: 164: 5: 5: 19: 10: 1: 1, and its preparation method is as follows:

[0040] 1. Dissolve anhydrous sodium acetate in ultrapure water to prepare a 0.2 mol / L sodium acetate solution, and adjust the pH of the sodium acetate solution to 5.4 with hydrochloric acid or sodium hydroxide to obtain a sodium acetate buffer.

[0041] 2. Dissolve chitosan and gelatin in sodium acetate buffer solution respectively, prepare 0.1% gelatin buffer solution and 0.1% chitosan buffer solution, and filter with 0.45 μm water filter membrane.

[0042] 3. Weigh 50 mg...

Embodiment 2

[0047]The embodiment of the present invention provides a theaflavin composition 2 for promoting wound healing, the main components of which include theaflavin-3-3'-digallate monomer, sodium acetate, chitosan and gelatin, the The mass ratio between theaflavin-3-3'-digallate monomer, sodium acetate, chitosan, and gelatin is 10: 164: 5: 5, and its preparation method is as follows:

[0048] 1. Dissolve anhydrous sodium acetate in ultrapure water to prepare a 0.2 mol / L sodium acetate solution, and adjust the pH of the sodium acetate solution to 5.4 with hydrochloric acid or sodium hydroxide to obtain a sodium acetate buffer.

[0049] 2. Dissolve chitosan and gelatin in sodium acetate buffer solution respectively, prepare 0.1% gelatin buffer solution and 0.1% chitosan buffer solution, and filter with 0.45 μm water filter membrane.

[0050] 3. Weigh 50 mg of theaflavin-3-3'-digallate monomer, ultrasonically dissolve it in 25 mL of 0.1% chitosan buffer solution, and slowly drop into 2...

Embodiment 3

[0054] The embodiment of the present invention provides a theaflavin composition 3 for promoting wound healing, the main components of which include theaflavin-3-3'-digallate monomer, glycerin, propylene glycol, triethanolamine and carbomer 940 , the mass ratio between theaflavin-3-3'-digallate monomer, glycerin, propylene glycol, triethanolamine and carbomer 940 is 10: 19: 10:1: 1, and its preparation method is as follows :

[0055] Its preparation method is as follows:

[0056] 1. Weigh 100 mg of theaflavin-3-3'-digallate monomer and dissolve it in 10 mL of water by ultrasonic.

[0057] 2. Add glycerin, propylene glycol and carbomer 940 according to the raw material formula, and let stand to obtain a gel solution.

[0058] 3. Add triethanolamine into the gel solution and stir to obtain.

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Abstract

The invention is applicable to the technical field of medicines, and provides a theaflavin composition for promoting wound healing as well as a preparation method and application thereof. The main component of the theaflavin composition for promoting wound healing is a theaflavin-3-3 '-digallate monomer or a theaflavin crude product; when the main component of the theaflavin composition is theaflavin-3-3 '-digallate monomer, the theaflavin composition further comprises a component A or a component B, or the theaflavin composition simultaneously comprises the component A and the component B; when the main component of the theaflavin composition is a theaflavin crude product, the theaflavin composition also comprises a component B; the theaflavin composition has the advantages of improving the stability of medicine molecules, increasing the bioavailability of the medicine molecules, improving poor dissolution, low treatment efficiency and the like of traditional medicines, can effectively promote synthesis of wound collagen, reduces infiltration of inflammatory cells, accelerates differentiation of newborn cells and formation of blood vessels, obviously promote the wound healing of diabetic mice, and the application value of potential wound healing is great.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a theaflavin composition for promoting wound healing, a preparation method and application thereof. Background technique [0002] Wound healing is a complex physiological process of restoring damaged tissue to its integrity. With the improvement of people's living standards, the incidence of diabetes is increasing year by year. Chronic wounds, one of the complications of diabetes, are difficult to heal. 85% of patients with chronic diabetic wounds have undergone amputation. Diabetic wounds impose a double burden on patients, both economically and healthily. An ideal wound treatment drug can promote wound healing, not only relieve the suffering of patients, but also reduce the economic burden of patients. [0003] Theaflavin-3-3'-digallate, TFDG (theaflavin-3-3'-gallate), is one of the main components of theaflavin in black tea. Crude theaflavins (TFs) have antiox...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K47/36A61K47/42A61K47/10A61K47/32A61K47/18A61K47/12A61K9/06A61P17/02
CPCA61K31/353A61K47/36A61K47/42A61K47/10A61K47/32A61K47/18A61K47/12A61K9/06A61P17/02A61K31/352A61K9/0014A61K31/722
Inventor 徐燕董旭陈小兵宛晓春刘增辉汪莹朱芦苇
Owner ANHUI AGRICULTURAL UNIVERSITY
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