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Flow synthesis process for the production of oseltamivir

A flow synthesis, suitable technology, applied in the direction of bulk chemical production, chemical instruments and methods, compounds of Group 5/15 elements of the periodic table, etc., can solve the problem of increasing final product cost, protecting group chemistry increasing reaction time, process Chemist restrictions, etc.

Pending Publication Date: 2021-11-19
ネルソンマンデラユニバーシティ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of these inherent hazards, process chemists are limited in the reaction parameters that can be used to maximize reaction efficiency and reaction yield
On the other hand, protecting group chemistry often increases reaction time while reducing overall yield, thereby increasing final product cost

Method used

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  • Flow synthesis process for the production of oseltamivir
  • Flow synthesis process for the production of oseltamivir
  • Flow synthesis process for the production of oseltamivir

Examples

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Embodiment Construction

[0067] The invention will now be described more fully hereinafter with reference to the accompanying drawings, in which some non-limiting embodiments of the invention are shown.

[0068] The invention, as described hereinafter, should not be construed as limited to the particular embodiments disclosed, but minor modifications and other embodiments are intended to be included within the scope of the invention.

[0069] Although specific terms are used herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

[0070] As used herein, throughout the specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

[0071] The terms and expressions used herein are for the purpose of description and should not be regarded as limiting. As used herein, the use of the terms "comprising", "comprising", "having", "including" and variations thereof are intended to...

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PUM

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Abstract

This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.

Description

technical field [0001] The present invention relates to the method for producing oseltamivir and its pharmaceutically acceptable salt, especially the flow synthesis method for producing the compound. Background technique [0002] Influenza is a serious respiratory viral infection causing significant morbidity and mortality due to annual prevalence and predictable pandemics. In the United States alone, 200,000 hospitalizations and 36,000 deaths are recorded each year. Furthermore, the virus affects approximately 20% of the world's population each year, resulting in approximately 500,000 deaths. [0003] Oseltamivir phosphate is one of a class of compounds known as neuraminidase inhibitors (NAIs), which are used to treat and prevent influenza. It is effective against influenza caused by influenza A virus and influenza B virus. [0004] Many methods and synthetic routes for the preparation of oseltamivir phosphate are described in the prior art. [0005] However, existing s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/12C07C233/52
CPCC07C231/12C07C2601/16C07C67/08C07C303/28C07C303/30C07C247/14C07F9/564C07F9/2466Y02P20/55C07C233/52C07C309/66C07C69/757C07C231/14
Inventor C·R·萨甘迪拉P·瓦茨
Owner ネルソンマンデラユニバーシティ