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A kind of mugwort leaf extract and its preparation method and application

A wormwood leaf extract and the technology of the extract, which are applied in the field of plant-derived antibacterial preparations, can solve the problems of low recurrence rate, complex formula and the like, and achieve the effects of simple preparation, expanded application scope and difficult drug resistance.

Active Publication Date: 2022-07-29
湖北嘉绘生物科技有限公司
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Problems solved by technology

The composition has a good therapeutic effect on various dermatophytes such as tinea pedis, athlete's foot, and onychomycosis, and has a low recurrence rate; however, there is still the problem that the formula is complicated and many auxiliary materials need to be added

Method used

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  • A kind of mugwort leaf extract and its preparation method and application
  • A kind of mugwort leaf extract and its preparation method and application
  • A kind of mugwort leaf extract and its preparation method and application

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preparation example Construction

[0036] Another typical embodiment of the present invention provides the preparation method of the above-mentioned argyi leaf refined extract, comprising the following steps:

[0037] (1) The macroporous adsorption resin on the above-mentioned argyi leaf extract is eluted with water, 10% (v / v) ethanol, and 20% (v / v) ethanol in turn to remove polysaccharide, protein and phenolic acid components; Pore ​​adsorption resin can be selected from D101, AB-8, ADS-4, ADS-8, SPD-100, LSA-20, XAD-5, preferably D101;

[0038] (2) eluting with 40% to 95% aqueous ethanol solution in sequence; preferably, eluting with 40%, 60%, and 95% aqueous ethanol solution in sequence, and wash until nearly colorless;

[0039] (3) Collect the eluents of each concentration respectively, remove the elution solvent, and obtain the refined extract of Artemisia argyi after freeze-drying; preferably, the elution solvent is removed by rotary evaporation under reduced pressure at 40-50°C.

[0040] Another typical...

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Abstract

The invention discloses an extract of Artemisia argyi, a preparation method thereof, and application of an antibacterial agent for dermatophytes, belonging to the technical application field of plant-derived antibacterial preparations. The antibacterial agent is the wormwood leaf extract obtained by ultrasonic extraction (5-75% ethanol) or ethanol reflux extraction with Chinese herbal medicine argyi leaf as raw material. Dermatophytes are highly inhibited. After being separated and purified by macroporous adsorption resin, the 40-95% ethanol fractions have different degrees of inhibitory activity against dermatophytes, and the 95% ethanol fraction is the most significant. At the same time, the main chemical compositions of the 95% ethanol separated fractions are iszelanin, emodin methyl ether, vitexin, and brown cyanidin. The invention can effectively inhibit dermatophytes, has the advantages of safety, high efficiency and low toxicity and side effects, and provides a new drug source for the prevention and treatment of dermatophytes such as hand and tinea pedis.

Description

technical field [0001] The invention belongs to the technical application field of plant-derived antibacterial preparations, and particularly relates to a natural antibacterial agent based on argyi leaf extract and a preparation method and application thereof. Background technique [0002] Dermatophytosis is a skin infection caused by the infection of human or animal skin, fur, and deck by dermatophytes, which are pro-colloid proteins, and can be infected on the head, hands, and feet. Dermatophytosis is widely prevalent all over the world, and is more prevalent in tropical and subtropical regions. The incidence in my country is also quite high. The clinical manifestations are mainly erythema, blisters, pustules and other skin lesions, with obvious itching. Different levels of symptoms appear, which troubles a large number of people. At present, a large number of studies have shown that the pathogenic bacteria of dermatophytes such as tinea corporis and tinea pedis are roughl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/282A61P17/00A61P31/10
CPCA61K36/282A61P17/00A61P31/10
Inventor 刘大会陈乐杜鸿志赵璐李金鑫朱芸芸
Owner 湖北嘉绘生物科技有限公司
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