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Application of SLC12A5 and inhibitor thereof

A technology of SLC12A5 and inhibitors, which is applied in the field of application of SLC12A5 and its inhibitors, can solve the problems that there are no relevant research and reports on the effect, and there are few studies, and achieve the goal of inhibiting cell proliferation and clone formation rate, and inhibiting the growth of subcutaneous tumors Effect

Active Publication Date: 2021-12-03
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This gene can significantly enhance cell proliferation, promote G1-S phase transition, and inhibit tumor cell apoptosis, but its role in other cancers has not yet been studied and reported
[0004] At present, there are very few studies on SLC12A5 outside the nervous system at home and abroad, especially in the liver

Method used

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  • Application of SLC12A5 and inhibitor thereof
  • Application of SLC12A5 and inhibitor thereof
  • Application of SLC12A5 and inhibitor thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: VU0240551 can significantly inhibit the proliferation ability of cholangiocarcinoma cells

[0051] The results of MTT experiment showed that the proliferation ability of RBE and HUCCT1 cells was significantly weakened after the intervention of VU0240551, as shown in figure 1 As shown in A and 1B, the proliferation ability of cholangiocarcinoma cells was significantly reduced compared with the control group when the corresponding concentration of VU0240551 was used to intervene with cholangiocarcinoma cells RBE and HUCCT1, and the difference was statistically significant (* represents P<0.05, *** represents P <0.0001).

[0052] Plate cloning experiments also showed that the proliferation ability of cholangiocarcinoma cells was significantly reduced after treatment with VU0240551. figure 2 Middle A shows that, compared with the control group, VU0240551 can significantly inhibit the colony formation rate of cholangiocarcinoma cell RBE, wherein P figure 2 Middl...

Embodiment 2

[0053] Example 2: VU0240551 significantly inhibits the growth of subcutaneous tumors in mice

[0054] PDX experiments show that the results such as image 3 , compared with the control group, VU0240551 intervention can significantly inhibit the growth of subcutaneous tumors, P<0.0001.

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Abstract

The invention relates to the technical field of biomedical engineering, and discloses application of SLC12A5 and an inhibitor of the SLC12A5. The biological function of the SLC12A5 is inhibited through the specific inhibitor, and compared with a control group, the SLC12A5 inhibitor can significantly inhibit bile duct cancer cell proliferation and clone formation rate, and also can significantly inhibit subcutaneous tumor growth, so that therefore, a new way for preparing the medicine for treating or improving the intrahepatic cholangiocarcinoma and treating the intrahepatic cholangiocarcinoma can be provided by taking the SLC12A5 as the target spot.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to the application of SLC12A5 and its inhibitors. Background technique [0002] Intrahepatic cholangiocarcinoma (ICC) is generally considered to originate from intrahepatic bile duct epithelial cells, and its incidence is on the rise worldwide. 5%-30%. The onset of ICC is occult, highly invasive, and easily invades the tissues around the liver, causing lymph nodes and distant metastasis, so most patients are already in the advanced stage when they are first diagnosed. Even in patients who are eligible for radical surgery, the postoperative recurrence rate is still 40%-80%, and the 5-year survival rate is only 20%-40%. ICC currently lacks effective treatment options, among which multiple tumors, lymph node metastasis, and distant metastasis are the key factors affecting postoperative tumor recurrence. In recent years, with the in-depth research on ICC-related tumor ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/501A61P35/00
CPCA61K45/00A61K31/501A61P35/00
Inventor 徐迅迪秦伟
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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