A kind of gradient elastic deformation differential drug release composite dressing and its preparation method

A technology of elastic deformation and elastic deformation rate, which is applied in the fields of pharmaceutical formulation, drug delivery, medical science, etc., can solve the problems of uncontrollable drug release and inability to achieve wound treatment, and achieves improved practicability and comfort, and high production efficiency. , the preparation method is simple

Active Publication Date: 2022-05-31
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing prepared by this patent is made by directly adding the drug into the spinning solution, and then electrospinning. The drug is evenly dispersed inside the fiber and released in the wound by diffusion, which cannot be controlled according to the stretching degree of the wound. The drug is released, so that the timely and effective treatment of the wound by the drug cannot be achieved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A preparation method of a gradient elastically deformed differential drug release composite dressing, the specific steps are as follows:

[0046] (1) Weaving gradient elastic deformation fabric:

[0047] (1.1) Designing the fabric structure: The gradient elastic deformation fabric is regarded as a plane structure, and the plane is composed of the concentric third region, the second region and the first region; the second region takes the edge line of the third region as the starting point. It is formed with an outer offset of 1cm, and the inner edge of the second region is collinear with the edge of the third region; the first region is formed by offsetting 1cm outward from the outer edge line of the second region, and the inner edge of the first region and the first region are formed. The outer edges of the II region are collinear;

[0048] The organizational structure of the fabric is: the first area is weft plain stitch; the second area is 1+1 rib organization; the ...

Embodiment 2

[0062] A preparation method of a gradient elastically deformed differential drug release composite dressing, the specific steps are as follows:

[0063] (1) Weaving gradient elastic deformation fabric:

[0064] (1.1) Designing the fabric structure: The gradient elastic deformation fabric is regarded as a plane structure, and the plane is composed of the concentric third region, the second region and the first region; the second region takes the edge line of the third region as the starting point. It is formed with an outer offset of 2cm, and the inner edge of the second region is collinear with the edge of the third region; the first region is formed with the outer edge line of the second region as a starting point and is formed with an outward offset of 2cm, and the inner edge of the first region and the first region are formed. The outer edges of the II region are collinear;

[0065] The organizational structure of the fabric is: the first area is 1+1 rib organization; the ...

Embodiment 3

[0079] A preparation method of a gradient elastically deformed differential drug release composite dressing, the specific steps are as follows:

[0080] (1) Weaving gradient elastic deformation fabric:

[0081] (1.1) Designing the fabric structure: The gradient elastic deformation fabric is regarded as a plane structure, and the plane is composed of the concentric third region, the second region and the first region; the second region takes the edge line of the third region as the starting point. It is formed with an outer offset of 2cm, and the inner edge of the II region is collinear with the edge of the III region; the first region is formed with the outer edge line of the II region as a starting point and an outward offset of 1.5cm, and the inner edge of the I region and The outer edges of zone II are collinear;

[0082] The organizational structure of the fabric is: the first area is weft plain stitch; the second area is 1+1 rib organization; the third area is 2+2 rib or...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention relates to a gradient elastically deformable differential drug release composite dressing and a preparation method thereof, comprising a gradient elastically deformable fabric and a drug-loaded hydrogel; the gradient elastically deformable fabric is regarded as a planar structure, and the plane is composed of a concentric third region The gradient elastic deformation in the gradient elastic deformation fabric refers to: the maximum elastic deformation rate of the fabric corresponding to the third area, the second area and the first area decreases in turn, and the third area The maximum elastic deformation rate of the corresponding fabric is greater than the maximum deformation rate of the joint skin; the elastic modulus of the fabric corresponding to the third area, the second area and the first area increases sequentially. The drug-loaded hydrogel is combined with the gradient elastically deformable fabric and located in the third area and the second area of ​​the gradient elastically deformable fabric; the maximum elastic deformation rate of the drug-loaded hydrogel is greater than the maximum deformation rate of the joint skin. The dressing prepared by compounding the hydrogel and the fabric of the invention can produce differential drug release effects according to the degree of wound tearing.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to a gradient elastic deformation differential drug release composite dressing and a preparation method thereof. Background technique [0002] Skin injury is one of the common diseases in human beings, which not only damages the patient's body function, but also is highly susceptible to infection from the external environment, resulting in further deterioration of the wound. Medical dressings are commonly used materials for the treatment of skin injuries. However, traditional wound dressings cannot meet the basic behavioral needs of frequently moving joints such as knees, wrists, shoulders, elbows and fingers. [0003] At present, the materials used for joint wounds are mainly medical elastic bandages, which play a basic role in fixing and protecting the joints. However, medical elastic bandages have no positive therapeutic effect on wounds. If the bandage is not firm, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/46A61L15/42A61L15/26A61L15/28C08F220/56C08F222/38
CPCA61L15/44A61L15/46A61L15/42A61L15/26A61L15/28C08F220/56A61L2300/402A61L2300/404A61L2300/602A61L2400/12C08L79/04C08L5/16C08L1/02C08F222/385
Inventor 高晶宋子钰王璐
Owner DONGHUA UNIV
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