Application of neojusticidin B in preparation of blood fat reducing drug
A blood lipid-lowering drug, the technology of Jucetidine, which is applied in the field of medicine, can solve the problems of bleeding, drug simultaneous treatment of hyperlipidemia and thrombosis, and significant differences in the efficacy of individual patients, so as to accelerate lipid clearance and reduce lipid absorption and the effect of operation
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Embodiment 1
[0033] Example 1: Preparation B lipid New kitsunenomago given
[0034] 1 Materials
[0035] 1.1 acanthus herbs
[0036] Acanthaceae autumn harvest herbs in 2019 in Wuhan City, Jiangxia District, and by Professor Wu Zhen Hubei University of Chinese Medicine identified as Acanthaceae Acanthaceae acanthus plants.
[0037] 1.2 Reagents
[0038] Ethanol, methanol, analytical grade, commercially available from Sinopharm Chemical Reagent Co., Ltd.; acetonitrile HPLC grade, available from Merck Chemicals Ltd; D101 macroporous resin, available from New Materials Technology Co. blue dawn.
[0039] 2 Methods
[0040] 2.1 New Acanthaceae aliphatic predetermined Preparation B
[0041] Acanthaceae take medicine 30kg, pulverizing, screening through a No. 2, 80% ethanol percolation percolate was concentrated under reduced pressure until no alcohol taste, extracted twice with ethyl acetate and the combined ethyl acetate solution under reduced pressure to recover the solvent, the residue 30% ethano...
Embodiment 2
[0044] Example 2: New kitsunenomago lipid lowering efficacy studies given B
[0045] 1 Materials
[0046] 1.1 Animals
[0047] SD rats were purchased from Experimental Animal Center of China Three Gorges University.
[0048] 1.2 Reagents
[0049] Serum total cholesterol kit, triglycerides kits, biochemical reagents were purchased from Eli Reiter Wuhan Biological Technology Co., Ltd.; high-fat diet was purchased from Hubei Province CDC; other reagents were analytical grade purchased from Sinopharm Chemical reagent Co., Ltd.
[0050] 2 Methods
[0051] 2.1 hyperlipidemia modeling
[0052] Take 30 SD rats, adaptive 7D rearing, blood total cholesterol, triglycerides, take the tail. The level of total cholesterol, use stratified random sampling packets rats, each rat appropriately adjusted total cholesterol and balanced distribution of initial body weight. After the start of the test, in addition to the basal diet control group, other groups were fed with high fat diet, continuous 30d....
Embodiment 3
[0063] Example 3: B - lipid kitsunenomago new antithrombotic efficacy of a given
[0064] 1 Materials
[0065] 1.1 Animals
[0066] SD rats were purchased from Experimental Animal Center of China Three Gorges University.
[0067] 1.2 Reagents
[0068] Hematoxylin dye, eosin dye available from Biological Technology Co., Xavier; sodium pentobarbital was purchased from Merck Chemicals Ltd.; the IAM iodoacetamide, Triethylammonium bicarbonate buffer (TEAB) were purchased from Sigma-Aldrich (Shanghai ) Ltd.; ModifiedTrypsin protease (mass spectroscopy grade) was purchased from PROMEGA Corporation; acetonitrile (mass spectroscopy grade), methanol (stage mass spectrometry), formic acid (mass spectroscopy grade), TMT 10Plex, Protein Ladder (prestained), ProteaseInhibitor Cocktail (protease inhibitor ), PierceTM BCA protein Assay kit, NUPAGE 10% BTGEL 1.0MM 12W, BreakerTM TCEP Solution (TCEP) was purchased from Thermo Fisher Scientific Ltd; BCA protein Assay kit was purchased from Eli Reit...
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