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Nano-antibacterial coating material, preparation method and internal plant based on nano-gold clusters

A nano-gold cluster and antibacterial coating technology, which is applied in the field of medical materials, can solve problems such as adverse reactions and copper ion allergies, and achieve the effect of improving antibacterial performance, good antibacterial performance, and avoiding copper ion allergy

Active Publication Date: 2022-07-01
深圳市亿歌润滑科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, some patients are allergic to copper ions contained in implants, which can easily lead to adverse reactions

Method used

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  • Nano-antibacterial coating material, preparation method and internal plant based on nano-gold clusters
  • Nano-antibacterial coating material, preparation method and internal plant based on nano-gold clusters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of nanometer antibacterial coating material based on gold nanoclusters comprises the following steps:

[0035] (1) Preparation of nano-gold cluster liquid:

[0036] According to the molar ratio of 1:2, take tetrachloroauric acid and p-mercaptobenzoic acid, mix them in ultrapure water, stir, and then add sodium hydroxide aqueous solution until the precipitate is dissolved again, and add 2 times the mole of tetrachloroauric acid. amount of sodium tetrahydroborate, stirring;

[0037] Hydrochloric acid was added to separate out all the nano-gold clusters, and after centrifugation, washed with ultrapure water, dried, dissolved in methanol, and used for later use.

[0038] (2) Preparation of nano antibacterial coating

[0039] Take the nano-gold cluster methanol solution, add vitamin C magnesium phosphate, ultrasonic treatment, add TiCl 4 and ZnCl 2 , ultrasonic treatment to obtain the nano-antibacterial coating material based on nano-gold clusters....

Embodiment 2

[0042] The preparation method of nanometer antibacterial coating material based on gold nanoclusters comprises the following steps:

[0043] (1) Preparation of nano-gold cluster liquid:

[0044] According to the molar ratio of 1:2, take tetrachloroauric acid and p-mercaptobenzoic acid, mix them in ultrapure water, stir, and then add sodium hydroxide aqueous solution until the precipitate is dissolved again, and add 2 times the mole of tetrachloroauric acid. amount of sodium tetrahydroborate, stirring;

[0045] Hydrochloric acid was added to separate out all the nano-gold clusters, and after centrifugation, washed with ultrapure water, dried, dissolved in methanol, and used for later use.

[0046] (2) Preparation of nano antibacterial coating

[0047] Take the methanol solution of gold nanoclusters, add sodium vitamin C phosphate, ultrasonically treat, and add TiCl 4 and ZnCl 2 , ultrasonic treatment to obtain the nano-antibacterial coating material based on nano-gold clust...

Embodiment 3

[0050] The preparation method of nanometer antibacterial coating material based on gold nanoclusters comprises the following steps:

[0051] (1) Preparation of nano-gold cluster liquid:

[0052] According to the molar ratio of 1:2, take tetrachloroauric acid and p-mercaptobenzoic acid, mix them in ultrapure water, stir, and then add sodium hydroxide aqueous solution until the precipitate is dissolved again, and add 2 times the mole of tetrachloroauric acid. amount of sodium tetrahydroborate, stirring;

[0053] Hydrochloric acid was added to separate out all the nano-gold clusters, and after centrifugation, washed with ultrapure water, dried, dissolved in methanol, and used for later use.

[0054] (2) Preparation of nano antibacterial coating

[0055] Take the nano-gold cluster methanol solution, add vitamin C magnesium phosphate, ultrasonic treatment, add TiCl 4 and ZnCl 2 , ultrasonic treatment to obtain the nano-antibacterial coating material based on nano-gold clusters....

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PUM

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Abstract

The invention discloses a nanometer antibacterial coating material, a preparation method and an internal plant based on nanometer gold clusters. The method includes the following steps: S01, preparing a nano-gold base solution; S02, mixing with vitamin C or its derivatives, and mixing with titanium ions and zinc ions to obtain the nano-gold cluster-based nano antibacterial coating material. The nanometer antibacterial coating material based on nano gold clusters obtained by the method of the present invention has good antibacterial performance for MRSA.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a nano-antibacterial coating material based on nano-gold clusters, a preparation method and an internal plant. Background technique [0002] Medical metal materials are the earliest materials used in orthopedics. In order to meet the needs of the continuous development of medicine, the surface modification of medical metal materials has become a research hotspot without changing the properties of the bulk material. The antibacterial properties of orthopedic medical metal materials are one of the important properties of medical metal materials. [0003] CN112190767A discloses a nanometer antibacterial coating material. The material can be attached to the surface of metal titanium to form an antibacterial layer. The material uses pMBA-AuNCs clusters as basic building blocks, and forms nano-metal oxide materials with a three-dimensional network structure wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/02A61L31/14A61L31/16B22F9/24B22F1/054B82Y40/00B82Y30/00
CPCA61L31/088A61L31/08A61L31/022A61L31/026A61L31/14A61L31/16B22F9/24B82Y40/00B82Y30/00A61L2300/404A61L2400/12A61L2300/102A61L2300/208A61L2300/408A61L2300/428A61L2300/606A61L2420/02A61L2420/04
Inventor 刘艳
Owner 深圳市亿歌润滑科技有限公司
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