Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine preparation of hydroxysafflor yellow A

A technology of hydroxy safflower and traditional Chinese medicine preparations, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas to increase anti-obesity effects, improve oral absorption, and increase oral bioavailability Effect

Pending Publication Date: 2021-12-10
SHAANXI UNIV OF CHINESE MEDICINE
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies on HSYA drug delivery systems mainly focus on lipid carriers that increase bioavailability by increasing the fat solubility of HSYA, but many studies lack the evaluation of the overall efficacy and safety before and after bioavailability improvement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine preparation of hydroxysafflor yellow A
  • Traditional Chinese medicine preparation of hydroxysafflor yellow A
  • Traditional Chinese medicine preparation of hydroxysafflor yellow A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Screening experiment of different deep eutectic solvents improving bioavailability of hydroxysafflower yellow A

[0019] The present invention has carried out the screening experiment that different deep eutectic solvents improve the bioavailability of hydroxysafflower yellow A, screened choline chloride-zinc chloride, choline chloride-oxalic acid, choline chloride-ethylene glycol , choline chloride-glycerin, glucose and choline chloride and other deep eutectic solvents, and found that hydroxysafflor yellow A not only has good solubility in glucose and choline chloride, but also promotes the highest bioavailability. Then the present invention screens the deep eutectic solvents of glucose and choline chloride with different concentrations of 10-100%, and finds that 90% concentration of glucose and choline chloride is the best for increasing the bioavailability of hydroxysafflor yellow A.

Embodiment 2

[0021] 1. Chemicals and medicinal materials

[0022] Hydroxysafflower yellow A and rutin (IS, purity >98.0%) were purchased from Shanghai Yuanye Biotechnology Co., Ltd. (Shanghai, China). D-glucose, choline chloride, pancreatin, pepsin from porcine gastric mucosa and mucin type II were purchased from Sigma (St. Louis, MO, USA). A high-fat diet (D12492, 60% calories from fat) was purchased from Research Diets (New Brunswick, NJ, USA). Liquid chromatography-mass spectrometry grade methanol and acetonitrile were purchased from Honeywell Burdick and Jackson (Muskegon, MI, USA), and HPLC grade formic acid was purchased from Merck (Darmstadt, Germany). All other reagents and solvents were of analytical grade. Deionized water was purified using the Millipore Milli-Q system (Bedford, MA, USA). Preparation of 90% GCH Deep Eutectic Solvent

[0023] Take glucose powder and choline chloride powder (molar ratio 2:5) in a beaker, stir and heat at 50°C to form a clear transparent liquid,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a traditional Chinese medicine preparation of hydroxysafflor yellow A. According to the traditional Chinese medicine preparation of hydroxysafflor yellow A, an optimal natural deep eutectic solvent capable of improving the hydroxysafflor yellow A is screened through a large number of experiments, and the result shows that the oral bioavailability of the hydroxysafflor yellow A can be remarkably improved by dissolving 90% glucose-choline chloride (90% GCH) in water. Compared with a water group, a 90% GCH group has the advantages that the relative oral bioavailability of the hydroxysafflor yellow A in the 90% GCH group is 326.93%. One-way intestinal perfusion experiments show that the absorption rate of the hydroxysafflor yellow A in jejuna in the 90% GCH group is increased by 2.95 times compared with that of an H2O group. Pharmacodynamic evaluation shows that 90% GCH hydroxysafflor yellow A can more effectively reduce body weight and correct steatohepatitis and dyslipidemia in fat rats induced by high fat diet. The 90% GCH not only can improve oral absorption of the hydroxysafflor yellow A, but also can increase the anti-obesity effect of the hydroxysafflor yellow A, and a remarkable technical effect is achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation of hydroxysafflower yellow A. Background technique [0002] Safflower (Carthamustinctorius L.) belongs to the Compositae family and has been used as a food additive and natural color for thousands of years. Safflower (dried florets) is widely used in the treatment of cardiometabolic diseases. Hydroxysafflower yellow A (HSYA) is a representative water-soluble quinochalcone C-glycoside pigment in safflower, which has various pharmacological activities inducing anti-cardiometabolic diseases. Safflower Yellow Pigment Injection is a yellow pigment extracted from safflower, with a content of not less than 70% HSYA. It is one of the top-selling traditional Chinese medicine products. In addition, only HSYA sodium chloride injection is used clinically in my country, but there are still many adverse reactions, such as allergic reacti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/7034A61K47/18A61K47/26A61P1/16A61P3/04A61P3/06
CPCA61K31/351A61K47/26A61K47/186A61K9/08A61P3/04A61P3/06A61P1/16
Inventor 乐世俊高欢王文晓唐于平
Owner SHAANXI UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com