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Application of astragalus smicus glycoside in resisting aging and inflammation aging

A technology of astragaloside and aging, applied in the field of medicine

Inactive Publication Date: 2021-12-21
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are no reports of its use in anti-aging

Method used

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  • Application of astragalus smicus glycoside in resisting aging and inflammation aging
  • Application of astragalus smicus glycoside in resisting aging and inflammation aging
  • Application of astragalus smicus glycoside in resisting aging and inflammation aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Establishment and Administration of C57BL / 6J Mouse Aging Model

[0058] Before the experimental modeling, the 10-month-old mice were adaptively fed for one week. After the mice adapted to the feeding environment, 37 C57 mice were randomly divided into control groups (12), and D-galactose / chlorinated Aluminum model group (30 rats, hereinafter referred to as D-galactose group or D-Gal).

[0059] During the modeling, the mice in both groups were injected with normal saline under the neck and gavaged for 2 days to adapt to the later administration method, and then injected 150 mg / kg / day of D-galactose under the neck of the model group regularly every day, and carried out Aluminum chloride 10 mg / kg / day was administered orally, and the normal control group was injected with the same volume of normal saline under the neck, and the modeling time was 63 days in total.

[0060] After the modeling was completed, the mice were randomly grouped: the weight of the mice, th...

Embodiment 2

[0061] Example 2 Ascarin improves body weight and mental state changes in aging mice

[0062] During the administration, the changes in body weight and mental state of the mice were observed and detected. Such as figure 1 As shown, we found that the weight gain of the mice in the D-Gal group was significantly lower than that in the normal control group after the 9th week. In terms of mental performance of the mice, the mice in the normal control group had high activity, good diet, significant weight gain, smooth coat, normal appetite, activity and response; the mice in the D-Gal group gradually became active after 5-6 weeks. The reactivity decreased obviously, the action was less and sluggish, it seemed listless, the amount of food and water intake decreased obviously, the body weight decreased, the hair was not smooth, and a small number of mice had unstable gait. After administration, the body weight of the mice in the D-Gal group was significantly lower than that of the n...

Embodiment 3

[0071] Example 3 Ascarin significantly improves the learning and memory function of aging mice

[0072] The Morris water maze test was used to detect the spatial learning and memory functions of mice in each group after 63 days of modeling.

[0073]The body of the Morris water maze is a white plastic vat with a diameter of 120 cm and a height of 50 cm. During the experiment, an appropriate amount of tap water was poured into the barrel, the water temperature was controlled at 26±1°C, and a bag of pure milk was poured in to avoid the interference of mouse odor. A recording system and an infrared camera were installed above the vat to record and analyze the movements of the mice in the water. The computer software automatically divides the inside of the vat into four quadrants (Ⅰ, Ⅱ, Ⅲ, Ⅳ). A white round escape platform with a diameter of about 12 cm is placed in the target quadrant (quadrant Ⅲ). About 1cm on the platform. Stick four black markers of different shapes on the i...

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Abstract

The invention relates to the fields of medicines and foods, in particular to application of astragalus smicus glycoside in resisting aging and inflammation aging. According to the application of astragalus smicus glycoside in resisting aging and inflammation aging, animal tests and cellular level tests show that the astragalus smicus glycoside has the effects of resisting aging, improving cognition, learning and memory ability, inhibiting glial cell activation and neuron loss, and reducing central and peripheral inflammation aging level and oxidative stress level. The research on the anti-aging effect of the astragalus smicus glycoside on a D-galactose / aluminum chloride aging model (hereinafter referred to as a D-Gal model) mouse finds that the astragalus smicus glycoside can be used for preparing an anti-aging product.

Description

technical field [0001] The invention relates to the fields of medicine, food and cosmetics, in particular to the application of ascarin in anti-aging and anti-inflammatory aging. Background technique [0002] Aging is an irreversible state of cellular arrest that is regulated by genetic and environmental factors. The characteristics of aging involve many aspects, including the accumulation of damage caused by reactive oxygen species, genome instability, and mitochondrial dysfunction. . Therefore, it is of great practical significance to provide a medicine for delaying aging. [0003] Astragalin (AST) is a natural flavonoid compound with molecular formula C 21 h 20 o 11 , the relative molecular mass is 448.39, the melting point is 177-179°C, and its molecular structure is shown in Formula I. [0004] [0005] Formula I [0006] At present, there is no report on its use in anti-aging. Contents of the invention [0007] In view of this, the present invention provid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P39/06A61P25/28A61P29/00A61P25/16A61K8/60A61Q19/08A23L33/125
CPCA61K31/7048A61P39/06A61P25/28A61P29/00A61P25/16A61K8/602A61Q19/08A23L33/125A23V2002/00A23V2200/302A23V2200/322A23V2250/21
Inventor 覃筱燕胡杨
Owner MINZU UNIVERSITY OF CHINA
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