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Food-based pH sensitive hydrogel and preparation method thereof

A hydrogel, sensitive technology, applied in the field of food or biomedicine, can solve the problems of no natural active substances found, long time for dissolution of chitosan, insufficient intake of nutrients, etc., to solve the problem of cytotoxicity, good pH sensitivity The effect of stability and suitable hardness

Active Publication Date: 2021-12-31
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, no food-based hydrogels prepared with jelly polysaccharides and chitosan have been found to be used for the delivery of natural active substances
In addition, the existing chitosan-based hydrogels take a long time to dissolve chitosan and have low efficiency. At the same time, chemical cross-linking agents and accelerators need to be added, which has defects such as poor product safety and insufficient intake of nutrients.

Method used

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  • Food-based pH sensitive hydrogel and preparation method thereof
  • Food-based pH sensitive hydrogel and preparation method thereof
  • Food-based pH sensitive hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Extraction of jelly jelly polysaccharides: take fresh jelly jelly, weigh after drying, soak in 80% ethanol overnight to remove alcohol-soluble small molecular substances. After evaporating the ethanol, add 20 times the volume of water and 0.5% sodium carbonate, stir and extract at 95°C for 3 hours, settle the supernatant with 80% ethanol overnight, centrifuge, redissolve the precipitate with water, remove the ethanol by rotary evaporation, and use Enzyme method and sevage method are combined to remove protein, centrifuged, and the supernatant is dialyzed with a dialysis bag with a molecular weight cut-off of 8000-14000 for three days, concentrated and freeze-dried to obtain jelly jelly polysaccharide powder.

[0034] Preparation of hydrogel: 500 mg of chitosan was dispersed in 50 ml of ultrapure water by vigorous shaking, and 50 ml of 2.0% acetic acid solution was added immediately to dissolve chitosan quickly and completely, forming 0.5% chitosan-1.0 % acetic acid stoc...

Embodiment 2

[0038] Extraction of jelly jelly polysaccharides: take fresh jelly jelly, weigh after drying, soak in 80% ethanol overnight to remove alcohol-soluble small molecular substances. After evaporating the ethanol, add 20 times the volume of water and 0.5% sodium carbonate, stir and extract at 95°C for 3 hours, settle the supernatant with 80% ethanol overnight, centrifuge, redissolve the precipitate with water, remove the ethanol by rotary evaporation, and use Enzyme method and sevage method are combined to remove protein, centrifuged, and the supernatant is dialyzed with a dialysis bag with a molecular weight cut-off of 8000-14000 for three days, concentrated and freeze-dried to obtain jelly jelly polysaccharide powder.

[0039] Preparation of hydrogel: 1000 mg of chitosan was dispersed in 50 ml of ultrapure water by vigorous shaking, and 50 ml of 2.0% acetic acid solution was added immediately to dissolve chitosan quickly and completely to form 1.0% chitosan-1.0 % acetic acid stoc...

Embodiment 3

[0044] Extraction of jelly jelly polysaccharides: take fresh jelly jelly, weigh after drying, soak in 80% ethanol overnight to remove alcohol-soluble small molecular substances. After evaporating the ethanol, add 20 times the volume of water and 0.5% sodium carbonate, stir and extract at 95°C for 3 hours, settle the supernatant with 80% ethanol overnight, centrifuge, redissolve the precipitate with water, remove the ethanol by rotary evaporation, and use Enzyme method and sevage method are combined to remove protein, centrifuged, and the supernatant is dialyzed with a dialysis bag with a molecular weight cut-off of 8000-14000 for three days, concentrated and freeze-dried to obtain jelly jelly polysaccharide powder.

[0045] Preparation of hydrogel: 1500 mg of chitosan was dispersed in 50 ml of ultrapure water by vigorous shaking, and 50 ml of 2.0% acetic acid solution was added immediately to dissolve chitosan quickly and completely to form 1.5% chitosan-1.0 % acetic acid stoc...

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Abstract

The invention discloses food-based pH sensitive hydrogel and a preparation method thereof. The method comprises the following steps of: (1) extracting mesona chinensis polysaccharide powder from mesona chinensis; (2) dispersing chitosan in ultrapure water through violent shaking, and immediately adding a 2.0% acetic acid solution, so that the chitosan is rapidly and thoroughly dissolved; and (3) dissolving a proper amount of mesona chinensis polysaccharide in ultrapure water; and slowly injecting the mesona chinensis polysaccharide solution into a chitosan-acetic acid stock solution under continuous stirring, and after violent stirring, standing at room temperature for 30 minutes to form the hydrogel. The hydrogel disclosed by the invention has excellent viscoelasticity, appropriate hardness, water binding capacity, non-toxicity and excellent biocompatibility and pH sensitivity, and the problems of cytotoxicity of the hydrogel, low oral utilization rate of natural active substances and the like can be solved to a certain degree. The hydrogel disclosed by the invention also has the characteristics of simple preparation method, high stability, easiness in degradation and the like and can be applied to delivery of natural nutrients or small molecular active substances in the field of foods or biomedicine.

Description

technical field [0001] The invention belongs to the field of food or biomedicine, and in particular relates to a food-based pH-sensitive hydrogel that can be used to deliver active substances and a preparation method thereof. Background technique [0002] In recent years, the population of patients with various chronic diseases has gradually moved towards a younger trend. Therefore, a reasonable increase in the intake of natural active substances such as polyphenols, flavonoids, natural pigments, vitamins, active peptides, etc. will help reduce the incidence. However, many natural active substances with poor water solubility, heat / light instability and low oral availability are less efficient for people to ingest from food. Therefore, there is a need for a food-based delivery vehicle that can be used to solve the above problems. [0003] Hydrogels are biological materials with a three-dimensional network structure, prepared from polymers through chemical or physical cross-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/12A61K47/36C08B37/00
CPCA61K9/06A61K31/12A61K47/36C08B37/0003
Inventor 谢建华杨俊申明月余强陈奕王远兴
Owner NANCHANG UNIV
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