Detection system for analyzing one or more particles

Abstract

According to the detection system for analyzing one or more particles, when a controller controls a driving device to enable a sampling needle to be located at a sample suction position, the sampling needle is communicated with a first fluid power source through a detection chamber, and the first fluid power source is controlled to provide power to enable the sampling needle to suck a sample at the sample suction position; after sample suction, the controller controls the driving device to enable the sampling needle to be located at a liquid suction level, the sampling needle is communicated with the first fluid power source through the detection chamber, and the first fluid power source is controlled to provide power to enable the sampling needle to suck cleaning liquid at the liquid suction level so as to clean the sampling needle. Therefore, the sample can be directly conveyed to the detection chamber, a sample loop for temporarily storing the sample is not needed, and the particle loss is reduced; and after the sampling needle sucks the sample, the sampling needle is cleaned in a manner of sucking the cleaning liquid, so that the sampling needle is simply and quickly cleaned.

Description

technical field [0001] The invention relates to the technical field of biochip detection, in particular to a detection system for analyzing one or more particles. Background technique [0002] Liquid phase suspension chip technology is a cutting-edge biomolecular detection technology integrating fluid technology, particle synthesis technology, biomolecular hybridization technology, and high-efficiency digital signal processing technology. Its principle is to combine known biomolecules (DNA, RNA, polypeptide, protein etc.) integrated on the surface of one or more microparticles to form a probe array, capture one or more analytes in the sample, and couple the analytes to one or more fluorescent substances (fluorescent dyes, fluorophores or Fluorescent particles) for identification, and then detected by optical methods. Liquid-phase suspension chip technology for biomolecular detection has significant advantages such as high precision, high throughput, fast speed, and low cost...

AI Technical Summary

Problems solved by technology

In the preferred form of this patent, as figure 1 As shown, its fluid processing subsystem includes a sample container 180, a sample loop 140, an imaging chamber 120, two valves (130 and 160) and a pump 170, etc., which require the sample loop 140 to temporarily store samples, and the sample loop 140 The existence of the pipe will lengthen the pipe required to drive the sample to the imaging chamber, and the sample suction process will become complicated, and because the particles to be analyzed will partially remain on the pipe wall or in the pipe during the process of driving the sample into the imaging chamber, it is relatively difficult A long pipeline will increase the loss of particles, which will affect the accuracy of the detection results

The patent also provides an alternative liquid circuit, such as figure 2 As shown, it does not have the sample loop 140 to save costs, but it cannot clean the sample probe with washing fluid, resulting in that after one sample is detected, when the next sample is detected, the previous sample remains in the sample probe, interfere with the test results

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