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Leave-on oral care compositions

An oral care and composition technology, applied in the field of oral care compositions, can solve the problems of limited residence time, no time to repair or even strengthen host tissues, etc., to achieve the effect of alleviating dry mouth, safe and effective feeling, and promoting gingival regeneration

Pending Publication Date: 2022-02-11
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the brushing has a limited dwell time of 2 minutes, it leaves little time to repair or even strengthen the host tissue

Method used

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  • Leave-on oral care compositions
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Examples

Experimental program
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Effect test

Embodiment

[0130] The following examples and descriptions further illustrate embodiments within the scope of the present invention. These examples are given for illustrative purposes only and are not to be construed as limitations of the invention, since many changes may be made therein without departing from the spirit and scope of the invention.

Embodiment A： Embodiment 1 to Embodiment 4

[0132] Examples 1 to 4 are the gel compositions shown in Table 1 below, wherein the amounts of the components are in % by weight. They can be suitably prepared by conventional methods selected by the formulator. Examples 1 to 4 are formulations of the invention according to the invention, made of sodium hyaluronate and a combination of at least two polymers, with or without allantoin.

[0133] Table 1: Gel compositions Example 1 to Example 4

[0134]

[0135]

[0136] *Sodium hyaluronate with a molecular weight of approximately 1,400,000 Da.

Embodiment B

[0137] Example B: Assay for Measuring Improved Wound Healing of Human Gingival Fibroblasts

[0138] Human gingival fibroblasts were used in vitro to assess the effect of migration on wound healing after treatment with the composition of the invention and a control composition. The method consists of three stages:

[0139] Phase 1 - Culture of Primary Human Gingival Fibroblasts ("HGF")

[0140] Human gingival fibroblasts were collected from dental extraction patients and washed with 5 mL of PBS (phosphate buffered saline). Cut the tissue into small pieces and place in a 15 mL centrifuge tube. Samples were digested with equal volumes of 1 mL of 8% dispase and 1 mL of 6% collagenase for 1 hour at 37 °C, during which time the samples were shaken every 15 minutes. Once the digestion process is complete, the tubes are centrifuged at 1100 RPM for 6 minutes at room temperature. After centrifugation, a pellet of cells formed at the bottom of the tube, separating them from the s...

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Abstract

Leave-on oral care compositions having good spreadability and improved retention property are provided for promoting gum health of a user. Said leave-on oral care compositions comprise a hyaluronic acid or a salt thereof, a polyacrylic acid as a mucoadhesive polymer and an additional polymer.

Description

technical field [0001] The present invention relates to an oral care composition comprising hyaluronic acid and a polymer combination for promoting gum health in a user. In particular, such oral care compositions provide a leave-on formulation with good spreadability, which helps to improve gingival wound healing. Background technique [0002] Gum diseases such as gingivitis and / or periodontitis cause acute and chronic inflammation of the gums in the oral cavity. "Gingivitis" is a milder form of the disease. Symptoms of gingivitis may include: bleeding gums; and red, swollen, or puffy gums. If left untreated, gingivitis can develop into "periodontitis." With periodontitis, the gums break away from the teeth and create spaces called "periodontal cavities," which can become infected with pathogenic bacteria. Bacteria exist as biofilms on tooth root surfaces. Bacteria in the biofilm may attack the gums and the underlying alveolar bone, which supports the teeth. These atta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/72A61Q11/00
CPCA61Q11/00A61K8/735A61K2800/594A61K8/8147A61K8/8176A61K2800/30A61K2800/87A61K2800/88A61K8/042A61K2800/92A61K8/4946
Inventor R·斯特兰德苏旸史运明T·山穆加姆王冠男李潇潇
Owner PROCTER & GAMBLE CO
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