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Mupirocin ointment and preparation method thereof

A technology of mupirocin and ointment, which is applied in the field of drug manufacturing, can solve the problems affecting the experience and curative effect of patients, uneven distribution of active ingredients, unsatisfactory drug efficacy, etc. The effect of small content change and good stability

Pending Publication Date: 2022-02-18
HAINAN JINXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented inventor describes an improved method for preparation of mastics containing certain drugs called motodiol oil (MDO). By adjusting different factors like pH value, type/weight ratio, solvent concentration, time during production process, and other variables, we found it was possible to create stable solutions without causing excessive pressure on sensitive areas such as blood vessels while also improving their effectiveness when used against specific conditions.

Problems solved by technology

This patented technical solution describes different types of anti-microbial agents called motorsulfuron or moxifloxacin which are commonly found on topical products like creams made up mostly of organic substances containing an amino sugar moiety attached through ester linkage between two sugars (glucose). These compounds have been shown effective against various microorganisms including Staphylococcus spp., Escherichia coli, Salmonella paratyphi B, Listerium monocytosis, Clostridium difficile, Bacillus subtilis varies depending upon their type of pathogenesis. However these drugs may cause allergens when applied directly onto sensitive areas due to they contain aldehydrins and other small groups present at certain positions within them. Additionally, some chemotherapy treatments use this agent but there could still result issues during administration if too much concentration needs to be achieved without causing side effects.

Method used

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  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A Most Star Ointment: Including the following weight materials: 30 Mororo Star, 300 polyethylene glycol 3350, 700 parts of polyethylene glycol 400, 20 parts propylene glycol, 10 龙 褐 萃 液, 8 Wishferome extract, 12 parts of butyl hydroxylholder ether, 11 vitamin E oil; the dragon blood brown extract is grinding dragon blood, over 50 mesh sieve, then loaded into the extraction of supercritical extracts In the kettle, use supercritical Co 2 For solvent, the extraction pressure is 18 MPa, the temperature is 61 ° C, the extraction time is 3 h, CO 2 The flow rate is 25 kg / h to perform supercritical extraction, which is a dragon platelet extract; the purple chrysanthemum extract is the upper portion of the fresh flower bud, which is pulverized, the purple car cone grazage, and the mass concentration is 90% ethanol heating to 80 ° C. After refluxing extraction 1 h, the mass volume ratio of water cone chrysanthemum and ethanol was 2:50, filtered, and the purple chrysanthemum extract...

Embodiment 2

[0024] A Most Star Ointment: including the following weight materials: 70 Mororo stars, 400 parts of polyethylene glycol 3350, 800 parts of polyethylene glycol 400, 30 parts propylene glycol, 30 龙 血 褐 萃 液, 22 Sex extract, 33-parts butylhydroxylholder ether, 28 vitamin E oil; the dragon blood brown extract is grinding dragon blood, over 80 mesh sieve, then loaded into supercritical extracts In the kettle, use supercritical Co 2 For solvent, the extraction pressure is 25 MPa, the temperature is 80 ° C, the extraction time is 5 h, CO 2 The flow rate is 35 kg / h to perform supercritical extraction, which is a dragon platelet extraction liquid; the purple chrysetryromile extract is part of the fresh flower buds, pulverized, golficular grazing, and adding a mass concentration of 95% to 100 ° C. After refluxing extraction of 5 h, the mass volume of water cone chrysanthemum and ethanol was 5:50, filtered, and the purple chrysanthemum extract was separated.

Embodiment 3

[0026] A Most Star Ointment: Including the following weight of the material: 50 Morros, 350 parts of polyethylene glycol 3350,750 parts polyethylene glycol 400, 25 parts propylene glycol, 20 龙 龙 褐 液, 15 Wishferome extract, 22 servant hydroxyapoxyl ether, 20 vitamin E oil; the dragon blood brown extract is grinding dragon blood, over 70 mesh sieve, then loaded into the extraction of supercritical extracts In the kettle, use supercritical Co 2 For solvent, the extraction pressure is 22 MPa, the temperature is 70 ° C, the extraction time is 4 h, CO 2 The flow rate is 30 kg / h for supercritical extraction to obtain a dragon blood brown extract; the purple chrysetryromile extract is a fresh flower bud, which is pulverized, and the purple glycery, and the mass concentration of 92% is heated to 90 ° C. After refluxing extraction 3 h, the mass volume of water cone chrysanthemum and ethanol is 3:50, filtered, and the purple chrysanthemum extract is separated.

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Abstract

The invention provides mupirocin ointment and a preparation method thereof. The mupirocin ointment is prepared from the following raw materials by weight: 30-70 parts of mupirocin, 300-400 parts of polyethylene glycol 3350, 700-800 parts of polyethylene glycol 400, 20-30 parts of propylene glycol, 10-30 parts of resina draconis extract, 8-22 parts of echinacea purpurea herb extract, 12-33 parts of butylated hydroxyanisole and 11-28 parts of vitamin E oil. The mupirocin ointment prepared by proportioning and combining the raw materials, respectively adding, mixing and stirring the raw materials and controlling the stirring environment and conditions is relatively high in content, good in stability and free of demulsification and crystallization phenomena, so that the active ingredients of the product are uniformly distributed in a matrix and are easy to smear, and the quality standard requirements are met.

Description

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Claims

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Application Information

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Owner HAINAN JINXING PHARMA
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