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Reforming effect of arginine to recessive harm of skin tissue of diabetic

A technology of arginine, diabetes, used in medicine and pharmacy

Inactive Publication Date: 2005-01-26
RUIJIN HOSPITAL ATTACHED TO SHANGHAI NO 2 MEDICALUNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no report on the use of arginine for the treatment of diabetic skin recessive lesions

Method used

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  • Reforming effect of arginine to recessive harm of skin tissue of diabetic
  • Reforming effect of arginine to recessive harm of skin tissue of diabetic
  • Reforming effect of arginine to recessive harm of skin tissue of diabetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Hidden Impairment Features of Diabetes

[0060] 1.1. Sugar content in skin tissue:

[0061] Methods: 26 rats were induced by intraperitoneal injection of streptozotocin (STZ) to form diabetic rats. Rats were sacrificed after induction for different time, and the sugar content in rat skin tissue was determined by biochemical method.

[0062] Results: The sugar content in skin tissue of diabetic rats killed 14 days after induction was 1.0699 mg / g skin tissue, and the sugar content in skin tissue of diabetic rats killed 8 weeks was 2.099 mg / g skin tissue, the difference between the two groups was significant (P<0.01 ); compared with normal rats (0.3963mg / g skin tissue), the sugar content in the skin tissue of diabetic rats was significantly increased (P<0.01).

[0063] 1.2. Detection of glycation end products in skin tissue:

[0064] Methods: The method was the same as 1.1, and the rats were sacrificed after 8 weeks of induction, and the end-glycosylation products in ra...

Embodiment 2

[0077] The therapeutic effect of arginine on hidden damage of diabetes mellitus

[0078] In this example, different doses of arginine were administered to diabetic rats by intragastric administration, and the dosage regimens were: 25 mg, 50 mg, 100 mg, 200 mg / Kg body weight. The rats were killed at different times after the administration, and the same methods as in Example 1 were used for various determinations.

[0079] 2.1. Determination of sugar content in skin tissue:

[0080] The result is as figure 2 shown. The sugar content in skin tissue of diabetic rats was 2.0994mg / g skin tissue, that of normal rats was 0.3963mg / g skin tissue, and that of diabetic rats treated with arginine was 1.3808mg / g skin tissue. Compared with the simple diabetes group, the sugar content in the skin tissue of diabetic rats treated with arginine was significantly lower (P figure 2 ).

[0081] 2.2. Effects on the proliferation cycle of epidermal cells:

[0082] The result is as Figure 5 s...

Embodiment 3

[0090] Pharmaceutical compositions containing arginine

[0091] In this example, a pharmaceutical composition containing arginine for oral administration was prepared, and the dosage form was granules.

[0092] Arginine Hydrochloride

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PUM

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Abstract

The invention discloses the novel use of arginine in preparing therapeutic medicine compositions for treating skin recessive damage caused by diabetes, wherein the medicament can make the diabetes patient's skin recover to near the normal thickness.

Description

technical field [0001] The invention relates to the fields of medicine and pharmacy, and more specifically relates to the improvement effect of arginine on the "invisible damage" of diabetic skin tissue. Background technique [0002] Diabetes is a disease that seriously threatens human health. Clinically, it is common for diabetic patients to have thin skin, which is generally vulnerable to injury, and after injury, the wound healing is delayed or not healed. [0003] Currently, the commonly used drugs for clinical treatment of diabetes are sulfonylureas, biguanides and insulin. However, none of these drugs significantly improved the thinning of skin tissue in diabetic patients. [0004] Arginine is an essential amino acid. Since arginine crystals were purified in the late nineteenth century, arginine has been found to be closely related to growth and development, biochemical metabolism, immunity, etc., and has been widely used as an important nutrient. However, so far t...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/198A61P3/10A61P17/02
Inventor 陆树良谢挺葛奎
Owner RUIJIN HOSPITAL ATTACHED TO SHANGHAI NO 2 MEDICALUNIV
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