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A kind of terpenoid compound and its preparation method and application

A terpenoid and compound technology, applied in the field of medicine, can solve the problems of neurotoxicity, bone marrow suppression, limited clinical application, etc., and achieve obvious anti-cancer effect and simple operation.

Active Publication Date: 2022-04-15
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the widespread use of platinum-based metal antineoplastic drugs, some of their shortcomings are gradually exposed, such as poor compliance, bone marrow suppression, severe neurotoxicity, nephrotoxicity, and severe acquired drug resistance, which limit their clinical application. application

Method used

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  • A kind of terpenoid compound and its preparation method and application
  • A kind of terpenoid compound and its preparation method and application
  • A kind of terpenoid compound and its preparation method and application

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Embodiment Construction

[0043] In order to further understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. . Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0044] Unless otherwise specified, the reagents involved in the examples of the present invention are all commercially available products, which can be purchased through commercial channels.

[0045] One, the preparation method of compound of the present invention

[0046] (1) Instruments and materials:

[0047] AVANCEⅢ500 superconducting nuclear magnetic resonance instrument (Bruker, Switzerland); ABSCIEX 5600 +QTOF l...

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses a terpenoid compound and its preparation method and application. The terpenoid compound includes two compounds extracted and separated from lilac. The separation and preparation method is simple, and the pure compound can be obtained . The terpenoid compound of the present invention can significantly inhibit the growth of 10 kinds of cancer cells such as liver cancer cells (HepG2), breast cancer cells (MCF-7), cervical cancer cells (HeLa), have obvious anti-cancer effects, and are expected to be developed into new Anti-cancer drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a terpenoid compound and its preparation method and application, especially the application in the preparation of anticancer drugs. Background technique [0002] Cancer is a malignant disease that seriously threatens human health. Due to its characteristics of unlimited proliferation, transformation and easy dispersion and metastasis, the clinical manifestations are high recurrence rate and mortality. It has become a medical problem that plagues the world. According to the latest global cancer burden data in 2020 (provided by IARC), there will be 19.29 million new cancer cases and 9.96 million cancer deaths worldwide in 2020, of which 4.57 million are new cancer cases in China, accounting for 23.7% of the world, far exceeding the world Other countries. Globally, due to the aggravation of population aging, smoking, unhealthy diet and lack of exercise, the burden of c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/733C07C45/79C07C45/81A61K31/122A61P35/00
CPCC07C49/733C07C45/79C07C45/81A61P35/00C07C2602/28
Inventor 冯育林何明珍李志强杨世林李军茂欧阳辉张皓男崔玉顺
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE