Human bladder cancer gemcitabine drug-resistant cell strain and application thereof

A technology of gemcitabine and drug-resistant cells, applied in the field of cell engineering, can solve the problems of basic research on bladder cancer gemcitabine resistance, preparation of gemcitabine-resistant cell lines, etc.

Pending Publication Date: 2022-03-15
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Abstract
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Problems solved by technology

5637 is a good cell tool for human bladder cancer research, but at present, there is no gemcitabine-resistant cell line prepared from human bladder cancer cell line 5637 in China, which cannot satisfy the basic research of bladder cancer gemcitabine resistance

Method used

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  • Human bladder cancer gemcitabine drug-resistant cell strain and application thereof
  • Human bladder cancer gemcitabine drug-resistant cell strain and application thereof
  • Human bladder cancer gemcitabine drug-resistant cell strain and application thereof

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Embodiment Construction

[0013] The present application will be described in further detail below through specific embodiments in conjunction with the accompanying drawings. Wherein, similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many details are described in order to enable the application to be better understood. However, those skilled in the art can easily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the application are not shown or described in the description, this is to avoid the core part of the application from being overwhelmed by too many descriptions, and for those skilled in the art, it is necessary to describe these operations in detail Relevant operations are not necessary, and they can fully understand the relevant operations according to the description in the specification and general ...

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Abstract

The invention discloses a human bladder cancer gemcitabine drug-resistant cell strain, which is named as a human bladder cancer gemcitabine drug-resistant cell strain 5637-GEM-A1, and the preservation number of the human bladder cancer gemcitabine drug-resistant cell strain is GDMCC No: 61948. The drug-resistant index of the human bladder cancer drug-resistant cell strain meets the evaluation requirements of drug-resistant strains, and the human bladder cancer drug-resistant cell strain has important application prospects in the aspects of researching a bladder cancer drug-resistant mechanism, excavating a bladder cancer gemcitabine drug-resistant target, reversing bladder cancer cell drug resistance and guiding medication of patients.

Description

technical field [0001] The invention relates to the technical field of cell engineering, in particular to a gemcitabine-resistant cell line of human bladder cancer. Background technique [0002] Bladder cancer is one of the most common malignant tumors of the urinary system. Surgical hemiectomy assisted by chemotherapy is an important means to delay the progression of bladder cancer and prolong postoperative survival in patients with advanced bladder cancer. However, about 61% of patients with Tumors of the urinary system are naturally multi-drug resistant, leading to poor chemotherapy effects and easy recurrence after surgery. [0003] Gemcitabine is a new cytidine nucleoside derivative. Like cytarabine, gemcitabine is activated by deoxycytosine kinase and metabolized by cytidine deaminase after entering the body. Gemcitabine is a pyrimidine antineoplastic drug with the same mechanism of action as cytarabine. Its main metabolites are incorporated into DNA in cells and mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/09C12Q1/02
CPCC12N5/0693G01N33/5011
Inventor 黄卫人牛立慢刘凯清
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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