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Cognition and brain image data integration evaluation method for Alzheimer's disease

A technology for Alzheimer's disease and data integration, applied in the direction of nuclear methods, medical data mining, medical images, etc., can solve problems such as incomprehensible words, inability to write, incontinence, etc.

Pending Publication Date: 2022-03-15
BEIJING WISPIRIT TECH CO LTD
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AI Technical Summary

Problems solved by technology

(2) Obstacles in visuospatial skills: Can't accurately judge the location of objects, can't find my own room or bed, can't distinguish clothes from left to right, anyway
(4) Difficulty in writing: the written content words are not expressive, and even unable to write their own name
(8) Dyskinesia: walking back and forth aimlessly, opening and closing doors everywhere, incontinence, etc.

Method used

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  • Cognition and brain image data integration evaluation method for Alzheimer's disease
  • Cognition and brain image data integration evaluation method for Alzheimer's disease
  • Cognition and brain image data integration evaluation method for Alzheimer's disease

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Embodiment Construction

[0044] The technical solutions of the present application are described in detail below with reference to the accompanying drawings.

[0045] like figure 1 As shown, the cognitive and brain image data integration evaluation method for Alzheimer's disease according to the present invention includes the following steps:

[0046] Step I: Obtain the behavioral data of the subject's cognitive function multi-domain screening assessment;

[0047] Step II: Analyzing Multimodal Magnetic Resonance Imaging Data

[0048] 1. Quantitative analysis of the subject's hippocampal volume and shape based on the fixed-point analysis method.

[0049] 2. Computation of functional connectivity within and between brain functional networks

[0050] 2.1 Resting-state fMRI (functional magnetic resonance imaging) data preprocessing to correct possible deviations in the original fMRI data;

[0051] 2.2 Extract the brain functional network and calculate the functional connections within the brain functi...

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Abstract

The invention relates to the field of online auxiliary evaluation, in particular to a cognitive and brain image data integration evaluation method for Alzheimer's disease. According to the method, firstly, multi-field screening and evaluation of the cognitive function are carried out, the purposes of rapid screening and detailed evaluation of the cognitive function are achieved, then multi-mode magnetic resonance imaging data analysis is carried out, and the multi-mode magnetic resonance imaging data analysis comprises the steps of extracting hippocampus volume and shape analysis, calculating a function connection value of a cognitive-related brain function network, and calculating the cognitive-related brain function network. As an index in the aspect of neuroimaging, the brain function is evaluated. Carrying out cognitive and neural Bayesian joint modeling; and finally, classifying and identifying the specific change mode of the Alzheimer's disease by using supervised learning.

Description

technical field [0001] The invention relates to the field of online auxiliary evaluation, in particular to a cognitive and brain image data integration evaluation method for Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is an insidious and irreversible neurodegenerative disease. [0003] Mild Cognitive Impairment (MCI) is a prodromal state of Alzheimer's disease proposed by the predecessors, and it is an intermediate state between normal aging and dementia. Mild cognitive impairment can be used as a "predictor" of Alzheimer's disease. If this state can be detected early and given appropriate intervention treatment, the progression of Alzheimer's disease can be delayed. Therefore, the correct diagnosis of Alzheimer's disease, especially mild cognitive impairment in its early stage, is crucial to the prevention, early detection and therapeutic intervention of Alzheimer's disease. [0004] Screening and assessment of multiple areas of cognitive f...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16H30/20G16H50/70G06N20/10
CPCG16H50/20G16H30/20G16H50/70G06N20/10
Inventor 李诗怡王云霞李嘉马珠江王晓怡
Owner BEIJING WISPIRIT TECH CO LTD
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