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Mass spectrometry ion extraction device and method

A mass spectrometry analysis and extraction device technology, applied in the field of mass spectrometry, can solve the problems of increased cost, low efficiency, annihilation and the like

Pending Publication Date: 2022-04-12
谱视科技杭州有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most current schemes based on the sampling cone method adopt the direct extraction method, that is, guide the voltage on the ESI needle and the sampling cone or the air curtain plate, and add negative pressure suction to carry out ion sampling. less efficient
Therefore, the patent DE 102004045706A1 proposed a new design, adding an auxiliary electrode to the ion source to improve the ion extraction efficiency of the interface, but the auxiliary electrode will reduce the desolvation process time of ions, and many ions will be annihilated in the air curtain plate superior
In addition, there are some designs that increase the ion extraction efficiency by increasing the aperture of the sampling cone. This method is feasible, but the load of the vacuum pump needs to be increased, and the cost will increase simultaneously in commercial development.

Method used

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  • Mass spectrometry ion extraction device and method

Examples

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example 1

[0040] The device of the present invention is used as the atmospheric pressure ion extraction interface of atmospheric pressure mass spectrometry, such as Figure 5 , the ion beam bound by the electrostatic field enters the sampling chamber through the sampling cone. This part adopts sharpened quadrupole rods for ion collision cooling, and applies radio frequency voltage to constrain the radial movement of ions. The external connection of the foreline pump maintains ~2torr of vacuum. The ions then enter the high pressure ion transport assembly 5 through the second differential hole. In this example, a radio frequency quadrupole is configured. The partial vacuum is maintained by a molecular pump with a vacuum degree of ~10 -2 torr or so. The ions enter the final stage of the vacuum chamber through focused transmission, which is the mass analyzer of the mass spectrometer.

example 2

[0042] Such as Figure 6 As shown, this example is also realized based on atmospheric pressure mass spectrometry. The ions are extracted by the sampling cone after passing through the strong focusing electrode assembly 3 and enter the sampling cavity. The difference is that the back end of the sampling cone 402 is directly connected to another cone, which is called the extraction cone. The extraction cone also applies a DC voltage, and its functions include providing vacuum differential and For the ion channel, the vacuum between the two cones is also maintained at about 2 torr, and the pore diameter of the extraction cone is larger than that of the sampling cone 402 . Downstream of the extraction cone, a sharpened RF quadrupole is configured for collisional cooling of the ions. The ions pass through the differential aperture and finally enter the large chamber where the mass analyzer is located. Examples 1 and 2 both include a three-stage differential system. For this type ...

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Abstract

The invention discloses a mass spectrometry ion extraction device and method. The mass spectrometry ion extraction device comprises an ion source, an air curtain cavity, a sampling cavity and an ion optical assembly which are sequentially arranged, wherein the ion source is used for generating ions of an object to be detected; the inlet end of the air curtain cavity is composed of a conical air curtain plate with an air curtain hole, the side wall of the air curtain cavity is provided with a branch for providing air curtain air, a strong focusing electrode assembly is arranged in the air curtain cavity, and a slit is formed between one end, close to the air curtain hole, of the strong focusing electrode assembly and the inner wall of the air curtain plate; the sampling cavity comprises a sampling cone and a high-pressure ion transmission assembly, and a second differential hole is formed in the outlet end of the sampling cavity. According to the invention, the extraction interface is improved, the distance between the air curtain hole and the sampling cone is increased, ions extracted by the air curtain hole are focused by applying a spatial strong focusing electrostatic quadrupole electric field, and the density of an ion group is improved, so that the extraction efficiency of the sampling cone is improved, and the concentration of a solvent ion adduct is reduced.

Description

technical field [0001] The invention belongs to the technical field of mass spectrometry, and in particular relates to a mass spectrometry ion extraction device and method. Background technique [0002] A sample or analyte for analysis in a mass spectrometer is typically ionized in an atmospheric environment, and the ions are then introduced into the vacuum chamber of the mass spectrometer. This type of atmospheric pressure ion source has core advantages in sample ionization, but introducing ions from an atmospheric pressure ion source into a vacuum chamber usually requires an interface with excellent performance between the ion source and the vacuum chamber for efficient extraction of ions. Taking liquid phase tandem mass spectrometry (LC-MS / MS), which is widely used at present, as an example, common atmospheric pressure ion sources include electrospray (ESI), atmospheric pressure chemical ionization source (APCI), etc. After the sample is ionized, ions and other intermedia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/06H01J49/00
Inventor 华道柱王涛方奕彪吉海泉
Owner 谱视科技杭州有限公司
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