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Combined medicine of hypoxanthine and human immune globulin for injection

A technology of human immunoglobulin and immunoglobulin, applied in the direction of drug combination, active ingredients of heterocyclic compounds, antipyretics, etc., can solve problems that need to be improved

Active Publication Date: 2022-04-22
BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of human immunoglobulin for injection is only significant in females, and the effect in males needs to be improved (patent application 202010925913.X)
There is no report of hypoxanthine in the treatment of radiation injury

Method used

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  • Combined medicine of hypoxanthine and human immune globulin for injection
  • Combined medicine of hypoxanthine and human immune globulin for injection
  • Combined medicine of hypoxanthine and human immune globulin for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1I

[0037] Embodiment 1 IVIg combined with hypoxanthine for the treatment of radiation damage

[0038] 1. Method

[0039] 1.1.5Gy total body irradiation analysis of hematopoietic system injury.

[0040] 24 male mice were divided into 2 groups:

[0041] ①IVIg group, 12 rats;

[0042] ②12 rats in the IVIg+hypoxanthine group;

[0043] The VIg group was intravenously injected with IVIg once 5 minutes after total body irradiation, and then injected IVIg twice a week for two weeks, each dose was 0.3g / Kg body weight.

[0044] In the IVIg+hypoxanthine group, hypoxanthine was injected intraperitoneally once within 30 minutes before whole body irradiation, and IVIg was injected intravenously once 5 minutes after irradiation, and then IVIg was injected twice a week for two weeks, and hypoxanthine was injected intraperitoneally every two days. The dose of hypoxanthine for each injection is 50 mg / kg body weight; the dose of IVIg for each injection is 0.3 g / Kg body weight.

[0045] 1.2.12G...

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Abstract

The invention discloses a combined medicine of hypoxanthine and human immune globulin for injection, and belongs to the field of biological pharmacy. Researches show that the human immune globulin for injection has the effect of treating radioactive injury, and the treatment effect can be further enhanced by combining hypoxanthine and the human immune globulin for injection. Therefore, the combined medicine disclosed by the invention is of great significance to patients receiving radiotherapy and people accidentally receiving excessive irradiation.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals. Background technique [0002] Cancer is the second leading cause of death in human beings. Radiation therapy ("radiotherapy") is a widely used method of cancer treatment. The contribution rate to cancer treatment is as high as 18%, which is second only to surgery and significantly higher than chemotherapy and biological therapy. . However, it is unavoidable that radiation therapy is accompanied by varying degrees of acute and chronic organ damage represented by inflammation and fibrosis. Specifically, radiation therapy for head and neck tumors often leads to oral mucositis; radiation therapy for chest tumors often leads to chronic pneumonia; radiation therapy for pelvic and abdominal tumors often leads to diarrhea, chronic enteritis, and intestinal obstruction. However, hematopoietic injury represented by leukopenia and myeloid deviation, and gastrointestinal injury represented by enteritis an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K31/522A61P39/00A61P7/00A61P37/04A61P29/00A61P1/00
CPCA61K39/39525A61K31/522A61P39/00A61P7/00A61P37/04A61P29/00A61P1/00A61K2300/00A61P43/00C07K16/06A61K39/395A61K2039/505A61K9/0019Y02A50/30
Inventor 王宗奎崔明李长清徐俊程露
Owner BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI