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Kit for determining Kawasaki disease incidence and method for determining Kawasaki disease incidence

A judgment method and Kawasaki disease technology, applied in chemical instruments and methods, specific peptides, biological tests, etc., can solve the problems associated with doctors' subjectivity and misdiagnosis

Pending Publication Date: 2022-04-26
FUKUOKA CITY HOSPITAL ORG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the diagnosis of KD is likely to be accompanied by the subjectivity of doctors and problems such as misdiagnosis.

Method used

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  • Kit for determining Kawasaki disease incidence and method for determining Kawasaki disease incidence
  • Kit for determining Kawasaki disease incidence and method for determining Kawasaki disease incidence
  • Kit for determining Kawasaki disease incidence and method for determining Kawasaki disease incidence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0153] (Purpose)

[0154] In KD-affected patients, the amount of oxidized LDL (LAB) present in the plasma is significantly increased compared with healthy subjects, and it was verified using the LOX-1 protein, which is a receptor for LAB.

[0155] (method)

[0156] (1) Preparation of samples

[0157] (preparation of blood samples)

[0158] Blood was collected after informed consent was obtained from 16 KD patients diagnosed with KD according to KD diagnostic guidelines (Ayusawa, M., et al., 2005, Pediatr Int 47:232-234). For control purposes, blood was also collected from 5 normal control subjects and 7 disease control subjects in the same manner. Here, "normal control subjects" refer to apyretic control subjects without infectious diseases although they have a past history of food allergy, and "disease control subjects" refer to pneumonia, gastroenteritis, bacterial infection, viral infection ( Human metapneumovirus, RS virus) and other febrile diseases.

[0159] Blood c...

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Abstract

Provided are a biomarker for identifying the presence or absence of Kawasaki disease, and a kit and method developed using the biomarker and capable of directly and objectively determining the presence or absence of Kawasaki disease in a subject suspected of having Kawasaki disease. Provided is a kit for determining the incidence of Kawasaki disease, comprising a LOX-1 protein immobilized on the surface of a substrate and / or a portion thereof having an LAB-binding ability.

Description

technical field [0001] The present invention relates to a kit for determining Kawasaki disease and a method for determining Kawasaki disease. Background technique [0002] Kawasaki Disease (hereinafter sometimes referred to as "KD") is a febrile disease characterized by systemic vasculitis. It occurs mainly in children younger than 5 years old, and coronary artery lesions (CAL) occur in about 25 to 30% of cases without treatment, so it can become a risk of myocardial infarction caused by thrombosis, etc. factor. Therefore, KD is now recognized as a major cause of childhood-onset heart disease in developed countries (Non-Patent Documents 1 to 3). [0003] More than half a century has passed since Kawasaki disease was reported in 1967, but its etiology and relationship with adult cardiovascular diseases are still unclear (Non-Patent Documents 1 and 4). [0004] The environmental epidemiological study of the Children's Hospital of Toronto suggested that, according to epidemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/92G01N33/68C07K14/705
CPCG01N33/92G01N33/6893C07K14/705G01N2333/705G01N2800/32G01N2800/328G01N2333/775
Inventor 原寿郎坂爪洋
Owner FUKUOKA CITY HOSPITAL ORG