Capillary electrophoresis systems, related devices, and related methods

Abstract

A biological analysis device (100) for performing capillary electrophoresis includes a voltage section (124) configured to generate a voltage difference across a cathode (106) connector and an anode (116) connector, an optical detector system (112) configured to detect light emission from a sample, a temperature adjustment section (126) configured to adjust the temperature of the sample, and a cartridge fixing portion configured to receive at least a portion of a removable cartridge (102) containing one or more capillaries (104) and a separation medium container (118). The biological analysis device may include one or more actuators (122) configured to actuate components of the removable cartridge when the removable cartridge is received in the cartridge fixing portion. Devices and methods relate to biological analysis.

Description

[0001] This application is a divisional application of the invention patent application with the application number 201880024853.5, the application date is February 23, 2018, and the invention title is "capillary electrophoresis system, related devices and related methods". technical field [0002] The present disclosure relates to multiple capillary electrophoresis devices and related devices, systems and methods. Background technique [0003] A capillary electrophoresis device typically has certain major components including, for example, one or more capillaries (e.g., arranged in an array), a source of separation medium (e.g., a polymer) for providing medium to the capillaries, a sample injection mechanism, an optical detector assembly , an electrode and a source of anode buffer on one end of the capillary and a source of cathode buffer on the other end of the capillary. Capillary electrophoresis devices generally also include various heating components and zones to regul...

AI Technical Summary

Problems solved by technology

Multiple structural designs also increase the total number of components, complicate temperature control schemes, and increase the risk of component failure

[0005] Furthermore, the use of electrophoretic devices with multiple interconnect structures can be relatively complex

For example, attaching a source of separation medium (hereinafter "polymer") to a capillary array can be complicated and risks introducing air bubbles or other artifacts whenever the array is separated and attached to the polymer source

Furthermore, the user, not the manufacturer, typically must attach the buffer source to the array, and must do so several times during the life of the capillary array

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