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Maleimide carbazole compound and synthesis method thereof
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A technology of maleimide and maleimide, applied in organic chemistry and other directions, can solve problems such as complex synthesis steps, and achieve the effects of good group positioning and selectivity, scientific process and wide source of materials
Pending Publication Date: 2022-05-27
XIANGTAN UNIV
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Problems solved by technology
Existing synthetic methods of maleimidocarbazole compounds have complex synthetic steps, need to take multi-step synthetic processes to complete, or need to use metal catalysts and equivalent metal oxidants and other shortcomings
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Embodiment 1
[0104] The nuclear magnetic data of the product of Example 1 are as follows:
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Abstract
The invention mainly relates to a synthesis method of maleimidecarbazole and derivatives thereof, and adopts the technical scheme that maleimidecarbazole and derivatives thereof are prepared from 2-(3-indolyl) cyclohexanone compounds and maleic imide compounds as raw materials in an oxygenatmosphere under the action of an iodine catalyst and acid. The synthesis method overcomes the defects that the existing synthesis method of the maleimide and carbazole compound has complex synthesis steps, can be completed by adopting a multi-step synthesis process, or needs to use a metal catalyst and an equivalent metal oxidant, and the like. The method has the advantages of simple and mild reaction conditions, no need of adding a transition metal catalyst or a reaction solvent, simplicity and convenience in operation, wide raw material source, wide substrate range, good atom economy, high yield and the like. The maleimide carbazole derivative and the synthesis method thereof can be used in a plurality of industrial production fields such as medicines, pesticides, dyes, organic functional materials and the like.
Description
technical field [0001] The invention relates to a maleimidocarbazole compound and a synthesis method thereof, belonging to the field of organic synthesis. Background technique [0002] Maleimidocarbazoles are an important class of nitrogen-containing polycyclic aromatic hydrocarbons (NPAHs), widely distributed in a variety of pharmaceutical ingredients and bioactive molecules, with potent and broad-spectrum pharmacological activities, such as kinase inhibitors, Antibacterial, angiogenesis inhibitor, anticancer and antiproliferative. The existing methods for synthesizing maleimidocarbazole compounds have the disadvantages of complex synthesis steps, requiring multi-step synthesis processes, or requiring the use of metal catalysts and equivalent metal oxidants. SUMMARY OF THE INVENTION [0003] Therefore, the object of the present invention is to provide a maleimidocarbazole and its derivatives. Under the action of an iodine catalyst and an acid, in an oxygenatmosphere, t...
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