Novel coronavirus genome feature similarity measurement method

Abstract

The invention discloses a novel coronavirus genome feature similarity measurement method. The method comprises the following steps: obtaining a novel coronavirus genome to be analyzed and a coronavirus genome infected by other contrast animals; extracting virus genome characteristics of each coronavirus genome; calculating the occurrence frequency of the virus genome characteristics; traversing and searching common virus genome characteristics of the novel coronavirus, and carrying out numerical processing and normalization processing; performing fuzzy clustering on the normalized common virus genome characteristics of the novel coronavirus to obtain a novel coronavirus clustering center; and calculating the Euclidean distance between the normalized numerical characteristics of the coronavirus infected by other animals and the clustering center of the novel coronavirus for quantifying the similarity of the virus, predicting the homology and genetic relationship of the virus according to the quantification result, quantifying the similarity of the virus, and predicting the homology and genetic relationship of the virus according to the quantification result. The method is low in cost and high in speed, and experimental results are easy to obtain.

Description

technical field [0001] The invention relates to the field of viral genomes, and in particular to a method for measuring similarity of novel coronavirus genome features. Background technique [0002] Most of the current traditional medicine uses traditional bioinformatics tools, such as BLAST sequence alignment, to achieve genome similarity measurement. However, the traditional comparison method has large investment, slow speed, long cycle and great difficulty, and cannot achieve rapid and accurate measurement of gene similarity. Especially in the case of the rapid spread of the virus, it is impossible to make a quick judgment, timely and effectively analyze the homology of the virus, and provide a timely and reliable basis for treatment. SUMMARY OF THE INVENTION [0003] The present invention provides a novel coronavirus genome feature similarity measurement method to overcome the technical problems of large investment, slow speed, long cycle and high difficulty in tradit...

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Problems solved by technology

[0003] The invention provides a novel coronavirus genome feature similarity measurement method to overcome the technical problems of large investment, slow speed, long cycle and high difficulty in traditional gene similarity comparison methods

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