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High content imaging system for generating enhanced images and method of operation thereof

An imaging system and imaging technology, applied in the field of microscope systems, can solve problems such as time increase and large amount of time

Pending Publication Date: 2022-06-24
MOLECULAR DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It should be clear that combining the repetition of the focusing and positioning operations described above with scanning the plate to produce a high resolution image can take a significant amount of time
Furthermore, this time can increase significantly if multiple microplates must be imaged, or if the user of the HCIS must verify and / or adjust the positioning of the sample and / or the focus of the HCIS during imaging

Method used

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  • High content imaging system for generating enhanced images and method of operation thereof
  • High content imaging system for generating enhanced images and method of operation thereof
  • High content imaging system for generating enhanced images and method of operation thereof

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Embodiment Construction

[0014] As described in detail below, a high-content imaging system (HCIS) according to the present disclosure includes a stage on which a sample or a microplate with a sample may be disposed, one or more illumination sources, one or more objective lenses, one or more A plurality of filters, focusing devices, imaging sensors, machine learning systems, controllers, and one or more machine learning systems that can be used with the machine learning systems train the model. Each training model is associated with an input imaging configuration and an output imaging configuration, and includes data necessary to configure and train an untrained machine learning system (eg, a neural network or other deep learning system). For example, if the untrained machine learning system is a neural network, the trained model includes interconnections with respect to one or more convolutional layers, one or more neuron layers, and one or more pooling layers between them parameter. The trained mod...

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Abstract

A high content imaging system includes a stage, a controller, a machine learning system, and an image generator. The controller receives a request including an output imaging configuration, and in response, the controller: (1) selects a training model associated with the output imaging configuration, (2) determines an input imaging configuration associated with the training model, and (3) configures the high content imaging system according to the input imaging configuration. The machine learning system is configured using the training model such that when an image acquired using the input imaging configuration is provided to the machine learning system, the machine learning system generates an output image according to the output imaging configuration. The image generator generates an image of the sample on the stage and provides the generated image to the machine learning system, and in response, the machine learning system generates an output image according to the output imaging configuration.

Description

[0001] Related applications [0002] This application claims the benefit of priority to US Provisional Application No. 62 / 925,554, filed October 24, 2019, the entire contents of which are incorporated herein by reference. technical field [0003] The present subject matter relates to microscopy systems and, more particularly, to high-content imaging systems for generating enhanced images and methods of operating such systems. Background technique [0004] High-content imaging systems (HCIS) can be used to obtain microscopic images of one or more biological samples (eg, DNA, proteins, cells, etc.). The biological sample(s) can be placed in such wells of a microplate having a two-dimensional pattern of wells. Such microplates typically have 96 or 384 wells, but may have more or fewer wells. To acquire an image of the biological sample(s) disposed in such a microplate, the autofocus system of the HCIS focuses on each well or a portion of the microplate and acquires an image. ...

Claims

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Application Information

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IPC IPC(8): G06T1/20G06T1/00G06N20/00
CPCG06T3/4046G06N3/084G06N20/00G06N3/045G06T5/50G06T2207/10056G06T2207/20081
Inventor 阿夫鲁·I·科恩洪迪慧史蒂夫·卢克斯蒂芬·莱茵
Owner MOLECULAR DEVICES