Calcium-based biological material as well as preparation method and application thereof

A biomaterial, calcium-based technology, applied in the field of calcium-based biomaterials and their preparation, achieves the effects of good reproducibility, simple preparation method, and excellent photothermal heating effect

Active Publication Date: 2022-07-12
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is extremely rare to report that calcium-based biomaterials have good photothermal response properties to near-infrared light through surface chemical modification.

Method used

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  • Calcium-based biological material as well as preparation method and application thereof
  • Calcium-based biological material as well as preparation method and application thereof
  • Calcium-based biological material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In a calcium-based biological material of the present embodiment, the calcium-based substance is self-made hydroxyapatite nanoparticles (HANP), and the specific preparation process is as follows:

[0039] (1) Preparation of hydroxyapatite nanoparticles (HANP): 24 mL of CaCl with a molar concentration of 0.1 mol / L was added 2 solution, 24 mL of NaH with a molar concentration of 0.05 mol / L 2 PO 4 ·2H 2 O solution, 50 mL of deionized water and 50 mL of ethylene glycol solution were poured into a 200 mL beaker in turn, mixed with magnetic stirring, and then adjusted to pH 6.7 with 0.5 mol / L NaOH solution, and then the mixture was transferred to polytetrafluoroethylene In a microwave reaction kettle, put it into a microwave chemical workstation, and react at 110° C. for 30 minutes. After the reaction is completed, it is naturally cooled to room temperature, and the reaction product is collected by centrifugation, washed three times with absolute ethanol and deionized wate...

Embodiment 2

[0042] In a calcium-based biological material of this embodiment, the calcium-based substance is self-made hydroxyapatite nanoparticles (HANP), which is consistent with the preparation method in Example 1;

[0043] The difference between this example and Example 1 is that the quality of the gallic acid weighed is different, and is divided into 7 test groups according to the different concentrations, and the settings of the test groups are shown in Table 1;

[0044] Table 1: The mass of gallic acid added in test groups 1-7 and the concentration table in NaOH solution

[0045] GA(mg) GA concentration (mg / mL) HANP:GA Test group 1 20 0.4 1:0.4 Test group 2 50 1 1:1 Test group 3 100 2 1:2 Test group 4 200 4 1:4 Test group 5 300 6 1:6 Test group 6 400 8 1:8 Test group 7 500 10 1:10

Embodiment 3

[0047] A kind of calcium-based biological material of the present embodiment, its calcium-based substance is a self-made hydroxyapatite nanowire (HANW), and the specific preparation process is as follows:

[0048] (1) Preparation of hydroxyapatite nanowires (HANW): Dissolve 8 mmol of sodium oleate in 25 mL of deionized water at 70°C, fully dissolve and naturally cool to room temperature. 25 mL of an aqueous solution containing 2 mmol of calcium chloride was added dropwise with vigorous magnetic stirring. Stirring was continued for 30 minutes, then the obtained suspension was mixed with 25 mL of an aqueous solution containing 1.8 mmol of sodium dihydrogen phosphate dihydrate, and the reaction mixture was transferred to a 100 mL polytetrafluoroethylene stainless steel autoclave, sealed, and heated in an oven at 200°C for 36 Hour. The obtained hydrothermal product is washed three times with deionized water and absolute ethanol, and dried to obtain HANW;

[0049] (2) Preparation...

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Abstract

The invention discloses a calcium-based biological material as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The preparation method of the calcium-based biological material comprises the following steps: adding a calcium-based substance into a sodium hydroxide solution containing gallic acid, uniformly stirring, heating for reaction, and filtering, washing and drying after the reaction is finished to obtain the calcium-based biological material, the obtained calcium-based biological material has an excellent photo-thermal heating effect, and has light absorption and photo-thermal conversion properties under the irradiation of near-infrared light; meanwhile, according to the calcium-based biological material provided by the invention, gallic acid with good biocompatibility and a calcium-based substance with good biocompatibility are subjected to coordination binding, so that the calcium-based biological material can be applied to preparation of bone defect repair materials and preparation of bone tumor drugs, the preparation method is simple, and the preparation cost is low. And moreover, the coordination combination of calcium-based substances with various dimensions and shapes and gallic acid is facilitated, that is, the preparation method disclosed by the invention is wide in applicability and beneficial to actual production.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a calcium-based biological material and a preparation method and application thereof. Background technique [0002] Bone defects caused by trauma, tumor, or infection are common diseases in clinical practice, causing a huge burden to patients and society. Therefore, good artificial bone repair materials are expected to be an alternative to autologous bone transplantation or allograft bone transplantation. In addition, extracorporeal physical hyperthermia is a traditional treatment method, which is often used for the repair of superficial tissues such as skin and soft tissue. The preparation of new photothermal bone repair materials is expected to extend this non-invasive treatment method to deep bone. Tissue treatment provides a new treatment method and idea for bone regeneration and repair. [0003] There are many kinds of artificial bone repair biomate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/50A61K41/00A61P35/00
CPCA61L27/10A61L27/12A61L27/50A61K41/0052A61P35/00A61L2430/02A61L2300/416A61L2300/21
Inventor 赵静郑龙坡侯孝东陈峰魏富鑫谢伟
Owner THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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