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Blood coagulant as well as preparation method and application thereof

A technology of blood coagulant and solvent, applied in the field of blood coagulant and its preparation, can solve the problems of increasing burden on patients and high cost, achieve short coagulation time, excellent radiation resistance performance, and is conducive to long-term storage and sales Effect

Pending Publication Date: 2022-07-29
南雄阳普医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the blood coagulation effect of imported liquid coagulants is better, but the cost is expensive, which will undoubtedly increase the burden on patients. Therefore, it is necessary to develop a new generation of blood coagulants that can reach the international advanced level to replace imports and save medical costs.

Method used

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  • Blood coagulant as well as preparation method and application thereof
  • Blood coagulant as well as preparation method and application thereof
  • Blood coagulant as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Preparation of blood coagulant

[0045] First, 6.4 g of silicon dioxide sterilized by ethylene oxide and 6.96 mL of water were mixed uniformly by ultrasonic or homogenizing method, and a monodisperse silica mother liquor was prepared by a zirconium bead mill system. Take 5g of ethanol, add 1.36g of vinylpyrrolidone-vinyl acetate copolymer, stir for 10min, then add 12.8g of polyethylene glycol stearate, stir for 10min, add silica mother liquor and 67.48mL of water, stir for 30min . After fine filtration through a 250-mesh sieve, it is obtained.

Embodiment 2

[0046] Example 2 Dispersibility detection of blood coagulants

[0047] Visual observation shows that the prepared blood coagulant is a suspension liquid, the solute particles are uniformly dispersed in the solution, there is no agglomeration, no agglomeration of coarse particles, and no particles remain after sieving through 250 mesh.

Embodiment 3

[0048] Example 3 Detection of particle size distribution of blood coagulants

[0049] Measure 1mL of blood coagulant and dissolve it into 45mL of pure water, and use Malvern Nano S90 laser particle size analyzer to measure the average particle size of the blood coagulant in the range of 300-360nm.

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Abstract

The invention relates to the technical field of biological materials, and particularly discloses a blood coagulant as well as a preparation method and application thereof. The blood coagulant is prepared from nano silicon dioxide, a vinyl pyrrolidone-vinyl acetate copolymer, polyethylene glycol stearate and a solvent, wherein the mass ratio of the nano silicon dioxide to the vinyl pyrrolidone-vinyl acetate copolymer to the polyethylene glycol stearate is (1-5): 1: (1-10). The blood coagulant prepared by the invention is short in coagulation time, and the obtained serum is high in quality; irradiation sterilization can be performed, and the performance of a product subjected to irradiation sterilization, aging and other treatments is equivalent to that of a product before treatment; the product performance is not influenced while the validity period is prolonged to 1 year, and the phenomena of sedimentation and caking are avoided in the storage process; the clinical detection requirements can be met.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a blood coagulant and a preparation method and application thereof. Background technique [0002] Clinical medical test is the main means of clinical diagnosis. Among the samples for clinical test, 80% are venous blood samples, of which more than 60% are serum samples separated from venous blood. Serum sample refers to the supernatant part of the upper part after blood coagulation and high-speed centrifugation to separate blood cells and fibrin to the lower part. Therefore, the prerequisite for obtaining serum is that the blood is fully coagulated, and the occurrence of blood coagulation is a complex mutation process that is stimulated by external factors after the blood is separated from the body. At present, venous blood in clinical tests is usually collected by vacuum blood collection. The materials of vacuum blood collection tubes are divided into glass and orga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28
CPCG01N1/28
Inventor 陈万能何俊杰钟福玲刘甜钟永清
Owner 南雄阳普医疗科技有限公司
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