4results about How to "Easy to reconstitute" patented technology

The invention provides an acellular matrix particle freeze-dried implant as well as a preparation method and application thereof, and belongs to the technical field of soft tissue filling materials. The acellular matrix particle freeze-drying implant consists of an acellular matrix, a suspending aid and a freeze-drying protective additive, wherein the mass ratio of the acellular matrix to the suspending aid to the freeze-drying protective additive is (0.5-10): (0.5-10): (0.5-6); and the particle size of the cell matrix freeze-drying implant is 10-1000 [mu] m. The acellular matrix particle freeze-dried implant retains a natural three-dimensional structure and natural active components, and reduces immunological rejection caused by raw material sources after clinical use of an injection product; the composition is suitable for being injected to irregular defect positions for filling and repairing, is injected to a subcutaneous corium layer deep layer to a subcutaneous superficial layer to repair moderate to severe wrinkles or wrinkles, and has a good repairing effect.

The invention discloses a freeze-dried human rabies vaccine and a preparation method thereof, and belongs to the technical field of viral vaccines. The method comprises the following steps: (1) cell culture; (2) virus inoculation; (3) harvesting viruses; (4) concentration and purification: clarifying the harvested virus liquid through a filter, carrying out ultrafiltration concentration through an ultrafiltration membrane to obtain a concentrated solution, and purifying by adopting a column chromatography to obtain a chromatographic solution; (5) preparing a stock solution: inactivating and hydrolyzing the chromatographic solution to obtain a virus inactivation solution, and adding human serum albumin into the virus inactivation solution to obtain the stock solution; (6) preparing a semi-finished product: diluting with a stabilizer to prepare the semi-finished product, wherein the stabilizer comprises the following raw materials: human serum albumin, araboxylan, L-arginine hydrochloride, casein phosphopeptides, alpha-tocopherol nicotinate, a solvent and the like; and (7) preparing a finished product. The rabies vaccine disclosed by the invention is excellent in quality and stable in immune efficacy, and liquid is clear after redissolution.

The invention provides a drug carrier based on N-acetylglucosamine, a drug preparation and a preparation method. The drug carrier based on N-acetylglucosamine comprises N-acetylglucosamine and a cross-linking agent, the cross-linking agent is a compound with an aldehyde group or a ketone group, and the aldehyde group or the ketone group reacts with the deacetylated N-acetylglucosamine to generate one or more of a hydrazide bond, a hydrazone bond or an imine bond. The drug carrier based on N-acetylglucosamine shows remarkable advantages in the aspects of particle size distribution, drug loading capacity, encapsulation efficiency and cumulative drug release rate.

The present application provides a gelatin particle and a preparation method thereof, and a hemostatic fluid gelatin composition. The gelatin particle is a cross-linked gelatin particle, and the preparation raw material of the gelatin particle comprises gelatin and a high molecular material containing amino and / or carboxyl; the preparation process of the gelatin particle comprises the steps of forming a gelatin gel from the gelatin and crushing the gelatin gel, wherein the high molecular material is added to mix with the solution of the gelatin or the gelatin gel before or after the formation of the gelatin gel. The gelatin particle and the hemostatic fluid gelatin of the present application can quickly absorb the moisture in the blood after being applied to a bleeding wound, thereby increasing the concentration of red blood cells, blood coagulation factors and the like in the blood, accelerating the endogenous blood coagulation mechanism, and having a good hemostatic effect.