Medicine coated support frame of blood vessel

A vascular stent and drug technology, applied in the field of medical devices, can solve problems such as the incidence of vascular restenosis not being effectively controlled

Inactive Publication Date: 2005-03-02
维科医疗器械(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the incidence of vascular restenosis after stenting has not been effectively controlled

Method used

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  • Medicine coated support frame of blood vessel
  • Medicine coated support frame of blood vessel
  • Medicine coated support frame of blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then soak the stent in 1%-80% Valsartan (valsartan) or Losartan (losartan) ethanol solution for 1min-60min. After the stent is taken out, the stent is vacuum-dried at 40° C. to remove the solvent, and the valsartan or losartan drug-coated stent adsorbed by porous silica gel ceramics is prepared.

Embodiment 2

[0057] Embodiment 2: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then immerse the stent in a dichloromethane solution of Irbesartan (irbesartan) with a concentration of 1%-60% for 1min-60min. After the stent was taken out, the stent was vacuum-dried at 40° C. to remove the solvent, and the irbesartan drug-coated stent adsorbed by porous silica gel ceramics was prepared.

Embodiment 3

[0058]Embodiment 3: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then immerse the stent in a methanol solution of Candesartan (Candesartan) with a concentration of 1%-60% for 1min-60min. After the stent is taken out, the solvent is removed by vacuum drying at 40° C., and the candesartan drug-coated stent adsorbed by porous silica gel ceramics is prepared.

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Abstract

A medicine coated support frame for blood vessel is composed of netted tube as support frame, medicine, and carrier. The mentioned medicine may be sartan kind of medicine, including valsartan, losartan, irbesartan, candesartan, telmisartan, eprosartan, saprisartan, tasosartan and zolasartan. This invention adopts a medicine action path different from that in the post, it is to play the part from the receptor's blockade action, and the sartan kind of medicines is selected as the ATI receptor blocking agent. Its advantages are better control of the speed to release medicine and high effect on preventing the recurrence of angiostenosis.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug-coated vascular expansion stent, in particular to a sartan drug-coated vascular stent. The drug vascular stent can effectively prevent the occurrence of restenosis after stenting. Background technique [0002] Since vascular stents have been used as the main means of interventional treatment of cardiovascular and peripheral vascular occlusive lesions, this technology has developed rapidly, and currently accounts for more than 80% of the treatment of such diseases. However, the biggest defect of this technique is the occurrence of vascular restenosis after stenting. From the current statistics, the incidence of restenosis after stenting is about 15%-30%. The reason for vascular restenosis after stenting is that vascular smooth muscle cells are induced to proliferate excessively after the vascular intima injury caused by stent expansion, which leads ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/90A61K31/41A61L27/40A61M29/00
Inventor 曾敏常慧訾振军顾兴中陈毅生贾三庆王雷
Owner 维科医疗器械(苏州)有限公司
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