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Method of extracting Huperzine A from Chinese herbal medicine multi-layer tower

A technology of huperzine A and Melaleuca tower, which is applied in the field of extracting huperzine A from Chinese herbal medicine Melaleuca tower, can solve the problems of low purity and low yield, and achieve high product quality, improved yield, and competitiveness strong effect

Inactive Publication Date: 2005-06-22
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is just a new process for extracting huperzine A from the Melaleuca Tower for the problems of low yield and low purity in the above-mentioned prior art.

Method used

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Embodiment 1

[0018] The method steps of present embodiment extracting huperzine A are as follows:

[0019] (1), material preparation: selection of raw materials, cutting into sections, crushing to obtain coarse powder, and then pulverizing through superfine powder;

[0020] (2), impregnation: After pulverizing the raw material Melaleuca tower, soak it with tartaric acid dynamic circulation in the percolation tank for 45 hours, and drain once every 10 hours;

[0021] (3), Concentration: Put the percolation liquid into a vacuum concentration tank, and concentrate it under reduced pressure at 55°C to 8% of the original volume;

[0022] (4), extraction: adjust the pH value of the concentrated solution to about 8.5 with sodium hydroxide, extract 4 times with chloroform, then extract with 0.1% sodium hydroxide solution, put the obtained chloroform solution into the lye storage tank, and input the lye The extract storage tank, then extract twice with chloroform, put the chloroform extract into t...

Embodiment 2

[0028] The method steps of present embodiment extracting huperzine A are as follows:

[0029] (1), material preparation: selection of raw materials, cutting into sections, pulverization to obtain coarse powder, and then superfine powder pulverization;

[0030] (2), impregnation: After the raw material Melaleuca tower is crushed, it is soaked in a percolation tank with malic acid dynamic circulation for 60 hours, and the liquid is drained once every 10 hours;

[0031] (3), Concentration: Put the percolation liquid into a vacuum concentration tank, and concentrate it under reduced pressure at 65°C to 10% of the original volume;

[0032] (4), extraction: adjust the pH value of the concentrated solution to 9.5 with sodium hydroxide, extract 6 times with chloroform, then extract with 0.2% sodium hydroxide solution, put the obtained chloroform solution into the lye storage tank, and input the lye for extraction Liquid storage tank, then extracted 3 times with chloroform, put the ch...

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Abstract

A method for extracting huperzine A from Chinese herbal medicine Melaleuca, which comprises the following process steps in sequence: raw material treatment and crushing → impregnation → concentration → extraction (repeated) → column chromatography → crystallization → high performance liquid chromatography selection → concentration and drying → Finished product. This method adopts superfine powder as its raw material, and utilizes the preparative high-performance liquid chromatograph to carry out separation and purification, can make the yield reach 7 to 9 / 100,000, improve the yield by 30%, and the purity is also improved, reaching 98 More than %, the production can reach the scale of industrialization, the product quality is high, and the competitiveness in the international market is strong.

Description

(1) Technical field [0001] The invention relates to a method for extracting traditional Chinese medicine, in particular to a method for extracting huperzine A from Chinese herbal medicine Melaleuca pagoda. (2) Background technology [0002] The Chinese herbal medicine Melaleuca is the whole herb of the fern Huperzaceae Hupermus serrata. Because its production areas are spread all over the mountainous areas from south to north in my country, it has a wide range of production areas and many aliases. The aliases include snake foot grass and centipede grass. It is a perennial herb and is used by folks. Used to dissipate blood stasis and remove blood, reduce swelling and relieve pain, dehumidify, clear away heat and detoxify. Its main chemical components: huperzine A, B, melaleucaine, melaleucaine, melaleucaine and other alkaloids. [0003] Huperzine A is an original drug used in the treatment and prevention of Alzheimer's disease and the treatment of benign memory disorders in C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D221/22
Inventor 邢泽田冯素香
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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