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Biological chip with minimized reactor isolation structure height and its preparation method

A technology of isolation structures and biochips, applied in biochemical equipment and methods, biological testing, microbial measurement/inspection, etc., can solve problems such as inability to minimize thickness and complicated operation

Inactive Publication Date: 2005-06-29
CHENGDU KUACHANG SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the main disadvantage is that the operation is complicated, or the isolation structure between the reactors still cannot realize the thickness minimization

Method used

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  • Biological chip with minimized reactor isolation structure height and its preparation method
  • Biological chip with minimized reactor isolation structure height and its preparation method
  • Biological chip with minimized reactor isolation structure height and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: Multi-reactor biochip

[0071] The basic structure of the biochip in this example is as follows figure 1 shown.

[0072] In this example, the substrate used is a glass substrate, and the highly hydrophobic materials used are all liquid materials, which are "super-hydrophobic latex paint" (provided by Chenguang Chemical Design Institute, China), "organic silicon waterproof coating" (China Chengdu Chenguang Chemical Design Institute) and "Polyacrylate Coating" (provided by Chengdu Chenguang Chemical Design Institute, China).

[0073] In this embodiment, the size of the substrate 1 is 75 × 25 × 1mm (length × width × height), and the highly hydrophobic material is evenly applied in the isolation area on the substrate, and cured after drying at room temperature according to the instructions of the supplier. ,form figure 1 The coating isolation structure 2 shown in , forms 16 reaction cells 3 with the substrate, and the size of the reaction cells is 3mm×3mm. ...

Embodiment 2

[0090] Embodiment 2: Multi-reactor biochip

[0091] The basic structure of the biochip in this example is as follows figure 2 shown.

[0092] In this example, the substrate used is a glass substrate, and the highly hydrophobic materials used are all solid-phase materials, which are respectively "polytetrafluoroethylene adhesive tape" (provided by Chenguang Chemical Design Institute, Chengdu, China, with a static water contact degree of 117 degrees) ) and "nano textiles" (provided by China Zhoushan Tomorrow Nanomaterials Company, static water contact degree of 155 degrees).

[0093] In this embodiment, the size of the substrate 1 is 75×25×1mm (length×width×height). The highly hydrophobic material is perforated and bonded to the isolation area on the substrate. After drying at room temperature, a figure 2 The highly hydrophobic isolation structure 2 shown in , forms 16 reaction cells 3 with the substrate 1, and the size of the reaction cells is 4.5mm×4.5mm. The thickness of...

Embodiment 3

[0096] Example 3: Multi-reactor open flow biochip

[0097] The basic structure of the biochip in this example is as follows image 3 shown. The left side of the figure is a top view, and the right side is a cross-sectional view of a-a. The dotted line in the middle is the activated glass slide substrate 1. The size of the substrate is 75mm×5mm×1mm (length×width×height). The substrate is fixed on a liquid-feeding structure and The plastic forming plate of the liquid outlet structure, the shape size of the forming plate is 80mm×25mm×1mm (length×width×height), the liquid feeding structure and the liquid outlet structure on it are grooves with a width of 2mm, and there are guides in the grooves. Fluid hydrophilic material. The periphery of the reaction pool on the substrate is a super-hydrophobic isolation structure 2 formed by coating a layer of super-hydrophobic "nano-silicon oxide CDS7" (provided by China Zhoushan Mingri Nanomaterials Co., Ltd.). According to the requirement...

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Abstract

The invention discloses a biochip and a preparation method of a reactor isolation structure height minimized, wherein the isolation structure is mainly a highly hydrophobic material layer with a surface static water contact angle of at least 80 degrees, and the thickness of the highly hydrophobic material layer is at most 1000um. Because the present invention minimizes the height of the isolation structure, it is easier to realize the maximum number of reactors and the minimum amount of sample addition.

Description

Technical field: [0001] The present invention relates to a biochip, in particular to a biochip with minimized reactor isolation structure and its preparation method, in which a highly hydrophobic material is combined on a hydrophilic solid phase carrier substrate to form or participate in the formation of a controlled liquid phase medium The flow reactor isolation structure, due to the use of the surface effect of the highly hydrophobic material and the conventional hydrophobic material, makes it easier to minimize the height of the reactor isolation structure, and finally achieves the purpose of reducing the cost of biochip detection. Background technique: [0002] Biochip, also referred to as chip in the present invention, is a qualitative and / or quantitative detection product. It reacts specifically with target molecules in biological samples, and then identifies the results of the specific reactions. [0003] Currently the most commonly used biochips are peptide chips a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68G01N27/00G01N33/50G01N33/543G01N33/552G01N33/68
Inventor 邹方霖陈春生王建霞陈宁
Owner CHENGDU KUACHANG SCI & TECH CO LTD
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