Use of aspergillus fumigatus in preparing anti inflammatory immunosuppressant

A technology of Aspergillus fumigatus, immunosuppression, applied in the directions of anti-inflammatory agents, antipyretics, drug combinations, etc., can solve problems such as no reports and the like

Inactive Publication Date: 2006-07-26
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In terms of its pharmacology, especially its anti-inflammatory immunosuppressive effect, there is no report so far

Method used

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  • Use of aspergillus fumigatus in preparing anti inflammatory immunosuppressant
  • Use of aspergillus fumigatus in preparing anti inflammatory immunosuppressant
  • Use of aspergillus fumigatus in preparing anti inflammatory immunosuppressant

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] Aspergillus fumigatus (Fumigaclavine C) is obtained from Cynodon dactylon (Cynodon dactylon) Aspergillus sp. endophytic fungi (strain number: CY018) A kind of indole alkaloid isolated from the solid fermentation product of ) (see attached figure 1 ). It is a white needle-like crystal (chloroform / methanol (V / V: 10 / 1)), melting point 192-194°C, IR: v max KBr (cm -1 )3401.5, 3058.2, 2961.7, 1715.7, 1609.4, 1460.9, 1381.0, 1260.8, 749.3; EIMS: 366, 307 (100%), 291, 238, 194, 108, 82, 43; ESIMS: 365 [M-H] - ;ESIMS:367[M+H] + ; 1 H(500MHz) and 13 C (125 MHz) NMR structural analysis is shown in Table 1.

[0040] position

[0041] s: singlet, d: doublet, t: triplet, br: broad

[0042] Fumigaclavine C (Fumigaclavine C) intraperitoneal injection has a significant improvement effect on the liver damage of mice caused by Con A, and its effect includes reducing the increase of transaminase in the serum of Con A model mice (Table 2), improving liver The pathologic...

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Abstract

A fumigaclvine C is extracted from the fermented solid of aspergillus fumigatus (CY018) growing in cynodon dactylon and has high action to improve the mouse's liver injury caused by Con A. It can be used to prepare medicines for treating hepatitis, rheumatoid arthritis, lupus erythematosus, allergic dermatitis and graft rejection.

Description

1. Technical field [0001] The invention belongs to the technical field of biopharmaceuticals. 2. Background technology [0002] Since the chemical structure of Aspergillus fumigatus C (Fumigaclavine C) was reported for the first time in 1977, there are quite few related studies on this compound and they all focus on its extraction, separation and structural identification. In terms of its pharmacology, especially its anti-inflammatory immunosuppressive effect, there is no report so far. 3. Contents of the invention [0003] The purpose of the present invention is to study the application of Aspergillus fumigatus Wen C in anti-inflammatory immunosuppressive drugs. [0004] Technical scheme of the present invention: [0005] 1. Extraction, separation and identification of Aspergillus fumigatus Wenbing [0006] Aspergillus fumigatus (Fumigaclvine C) is isolated from the endophytic fungus Aspergillus fumigatus (strain number: CYO18) of Cynodon dactylon. [0007] 1) Source ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D457/00A61K31/48A61P1/16A61P29/00A61P19/02A61P17/00A61P37/06
Inventor 谭仁祥徐强赵颖刘俊彦王俊
Owner NANJING UNIV
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