Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method

A cardiovascular and sustained-release technology, applied in the field of traditional Chinese medicine sustained-release preparations for the treatment of cardiovascular diseases and the preparation thereof, can solve the problems of large fluctuation of blood drug concentration, low content of effective components of traditional Chinese medicines, and inability to exhibit curative effects, etc. Coronary blood flow, long-lasting efficacy and safety, and the effect of reducing the frequency of medication

Inactive Publication Date: 2006-09-20
DONGLING MEDICINES INST SHENYANG CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the side effects of Chinese patent medicines are small, due to the low content of active ingredients in traditional Chinese medicines, the dosage is relatively large, and some medicines have a short half-life in the human body, so they need to be administered several times a day, which is not only inconvenient to take, but also easy to miss doses
What is more serious is that the drug concentration in the blood fluctuates greatly due to multiple administrations, and there are peaks and valleys. When the blood concentration is high, it will exceed the therapeutic concentration range and increase side effects. When it is low, it is below the effective therapeutic concentration, so that it cannot show curative effect

Method used

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  • Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method
  • Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Sustained-release agent of the present invention is made up of following raw materials by weight ratio:

[0049] Epimedium total flavonoids: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methylcellulose: magnesium stearate = 60:27:9:8:1

[0050] The method that it is prepared into tablet comprises the following steps:

[0051] a. Take Epimedium herbs, chop them, add water to decoct twice, add 20 times the amount of water for the first time, decoct for 2 hours, add 10 times the amount of water for the second time, decoct for 2 hours, combine and filter the decoction, and concentrate the filtrate To a relative density of 1.10 (80°C), add ethanol until the alcohol content reaches 70%, let it stand, filter or centrifuge, and recover the ethanol from the filtrate under reduced pressure, and concentrate to a clear paste with a relative density of 1.10, add 10 times the amount of 10% sodium carbonate (Na 2 CO 3 ) aqueous solution, stirred, filtered ...

Embodiment 2

[0055] Sustained-release agent of the present invention is made up of following raw materials by weight ratio:

[0056] Total flavonoids of Epimedium: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methylcellulose: magnesium stearate=45:30:8:25:3.

[0057] The method for preparing it into tablets is the same as in Example 1.

Embodiment 3

[0059] Sustained-release agent of the present invention is made up of following raw materials by weight ratio:

[0060] Total flavonoids of Epimedium: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methylcellulose: magnesium stearate = 90:5:1:1:0.1.

[0061] The preparation method is the same as in Example 1.

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PUM

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Abstract

A slow-releasing Chinese medicine for treating coronary heart disease and angia pectoris and lowering blood pressure is prepared from epimedium, microcrystalline cellulose, carboxymethyl starch sodium, hydroxypropyl methyl cellulose and magnesium stearate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating cardiovascular diseases, in particular to a traditional Chinese medicine slow-release agent for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris, common clinical diseases, are roughly equivalent to "chest pain" in Chinese medicine, which refers to chest pain, or even chest pain, back shortness of breath, wheezing, and inability to lie down. TCM syndrome differentiation of chest obstruction can be divided into "heart-blood stagnation syndrome", "phlegm turbidity congestion syndrome", "yin-cold stagnation syndrome", "heart and kidney yin deficiency syndrome", "qi-yin deficiency syndrome", "yang-qi deficiency syndrome" "(Refer to "Clinical Guidelines for New Drugs of Traditional Chinese Medicine"). The thoracic obstruction involved in the present invention belongs to the "Yang Qi Deficiency Syndro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K36/296A61K31/7048A61P9/10
Inventor 熊英
Owner DONGLING MEDICINES INST SHENYANG CITY
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