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Nanometer preparation of natural vitamin E
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A technology of natural vitamins and lipid nanoparticles, which can be used in emulsion delivery, powder delivery, antidote, etc., and can solve the problems of low bioavailability and poor absorption.
Inactive Publication Date: 2006-10-11
SOUTHEAST UNIV
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Problems solved by technology
The above-mentioned dosage forms using vitamin E have the deficiencies of low bioavailability and poor absorption to varying degrees
Method used
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Embodiment 1
[0036] 1. Weigh 0.5 g of stearic acid and 0.15 g of soybean lecithin, heat to 75°C and mix evenly to obtain a liquid oil phase;
[0037] 2. Weigh 0.1 g of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;
[0038] 3. Weigh 2.0g of S-40, dissolve it in 100ml of water, and heat to 75°C;
[0039] 4. Add the clarification system obtained in step 2 to 100 ml of water obtained in step 3, mix well, and emulsify with magnetic stirring equipment and ultrasonic treatment equipment for 30 minutes and 10 minutes respectively;
[0040] 5. Cool to room temperature to obtain the natural vitamin E lipid nanoparticle suspension.
Embodiment 2
[0042] 1. Weigh 6.0 grams of stearic acid, 4.0 grams of soybean oil, and 1.5 grams of soybean lecithin, heat to 75 ° C and mix evenly to obtain a liquid oil phase;
[0043] 2. Weigh 1.0 g of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;
[0044] 3. Weigh 10 grams of S-40, dissolve it in 1000 ml of water, and heat to 75°C;
[0045] 4. Add the clarification system obtained in step 2 to 1000 ml of water obtained in step 3, mix
[0046] 5. After uniformity, use a high-pressure homogenizer to emulsify for 3 minutes;
[0047]6. Cool to room temperature to obtain the natural vitamin E lipid nanoparticle suspension.
Embodiment 3
[0049] 1. Weigh 5.0 grams of soybean oil and 0.75 grams of soybean lecithin, heat to 60 ° C and mix evenly to obtain a liquid oil phase;
[0050] 2. Weigh 0.5 grams of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;
[0051] 3. Heat 500ml of water to 60°C;
[0052] 4. Add the clarification system obtained in step 2 to 500 ml of water obtained in step 3, mix well, and emulsify for 2 minutes with a high-pressure homogenizer;
[0053] 5. Cool to room temperature to obtain the natural vitamin E lipid nanoparticle suspension.
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Abstract
The preparation method of natural vitamin E lipid nanoparticle suspension is a preparation method of nano-medicine and cosmetic raw materials. Material: The emulsifier is 20:1~1:5. After mixing the lipid material and the emulsifier, heat it to the set temperature T, that is, T=60-80 degrees Celsius, and obtain a liquid oil phase after melting; add natural vitamin E to the In the liquid oil phase, stir and mix evenly to obtain a clarified system; add the above clarified system to water at the same temperature as the set temperature T, mix uniformly, and emulsify for 1-60 minutes to obtain natural vitamin E lipid nanoparticles. Lipid nanoparticles include lipid materials and vitamin E, and their forms are specifically divided into: lipid materials are a material that is a solid phase at room temperature or a mixture of multiple materials, and the final nanoparticles are called solids. Lipid nanoparticles or nanostructured lipid carriers.
Description
technical field [0001] The invention relates to a method for preparing nano-medicine and cosmetic raw materials, in particular to a method for preparing natural vitamin E lipid nanoparticle suspension. Background technique [0002] Vitamin E is a fat-soluble antioxidant, which can resist the damage of free radicals in the body and scavenge free radicals, inhibit the production of peroxides, and participate in various metabolic processes in the body. Vitamin E can enhance the blood flow of skin capillaries, increase the resistance of blood vessels to cold, maintain the normal permeability of capillaries, and delay the atrophy and degeneration of skin and some organs. Vitamin E, also known as tocopherol, can affect the reproductive function of human beings. At present, natural products can be prepared. For external use, it has the effects of moisturizing, protecting against ultraviolet rays, and slowing down the deposition of pigment or lipofuscin. Some derivatives of vitami...
Claims
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