Iodine microsphere clathrate compound and its preparation method and uses

A technology of iodide ion and potassium iodide, which is applied in the field of Hepu iodine, can solve the problems of iodine preparation packaging, storage and transportation difficulties, the inability to greatly improve the solubility of iodine, and the inability to eliminate mucosal irritation, etc., to achieve the disappearance of bad smell and stability Enhanced, reduced mucosal irritation effect

Inactive Publication Date: 2006-11-08
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +2
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The iodine preparations prepared by the above method all have shortcomings in a certain aspect
Forming a soluble complex between potassium iodide and iodine or adding organic solvents such as glycerin, ethanol, and vegetable oil can improve the solubility of iodine, but it is difficult to cover up the smell of iodine, and it cannot eliminate its irritation to mucous membranes.
It is also difficult to avoid the sublimation of iodine for the iodine preparations prepared by the above several methods, which brings difficulties to the packaging, storage and transportation of these iodine preparations.
The use of Chinese patent 90106682.6 to include iodine molecules with β-cyclodextrin can effectively cover up the unpleasant smell of iodine, reduce the irritation of iodine to the mucous membrane, and improve the stability of iodine, but it cannot greatly increase the iodine in water. Solubility

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: prepare a kind of liquid Wo Pu iodine

[0027] (1) Weigh 7g of hydroxypropyl-β-cyclodextrin, dissolve it in 100ml of distilled water, stir to make it all dissolve until the solution is clear;

[0028] (2) Weigh 1.8 g of potassium iodide and dissolve it in a small amount of distilled water to obtain solution A. Weigh 1.2g of iodine and grind it in solution A to make it all form a solution, and pour the solution into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0029] (3) Stir the mixed solution for 10 minutes, observe the solution until it is clear and transparent, and obtain a kind of liquid wopiodine.

Embodiment 2

[0030] Embodiment 2: prepare a kind of solid Wopu iodine

[0031] (1), (2), (3) are the same as embodiment 1;

[0032] (4) Concentrate the liquid Wopu iodine and dry it under reduced pressure to obtain a solid Wopu iodine.

Embodiment 3

[0033] Embodiment 3: prepare another kind of liquid wop iodine

[0034] (1) Weigh 7g of hydroxypropyl-β-cyclodextrin, dissolve it in 100ml of distilled water, stir to make it all dissolve until the solution is clear;

[0035] (2) Weigh 1.2 g of sodium iodide and dissolve it in a small amount of distilled water to obtain solution A. Weigh 1.2g of iodine and grind it in solution A to make it all form a solution, and pour the solution into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0036] (3) The mixed solution was stirred for 10 minutes, and the solution was observed until it was clear and transparent, and another liquid wopiodine was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to a kind of Hepu iodine for treating diseases such as chronic pharyngitis, oral mucosal ulcer, chronic gingivitis, periodontitis, acute and chronic pharyngitis, tonsillitis, iodine deficiency and its preparation method and application. Wopu iodine contains hydroxypropyl-β-cyclodextrin, iodine and iodide ion, wherein the molecular molar ratio of iodine to iodide ion and hydroxypropyl-β-cyclodextrin is 1:1~10:1~100. The invention utilizes cyclodextrin inclusion technology, solvent method and grinding method to form a microcapsule-like inclusion compound between iodine and iodide ion complexes and hydroxypropyl-β-cyclodextrin molecules. The clathrate can be used to prepare various iodine-containing products. Compared with other iodine-containing products, the clathrate improves the solubility of iodine, reduces iodine mucous membrane irritation, covers the bad odor of iodine, and shortens the sterilization time of iodine.

Description

technical field [0001] The invention relates to Wopu iodine for treating diseases such as chronic pharyngitis, oral mucosal ulcer, chronic gingivitis, periodontitis, acute and chronic pharyngitis, tonsillitis, iodine deficiency, and its preparation method and application. Background technique [0002] Iodine has been used as a disinfectant for a long time, and high-concentration iodine solutions have a strong inactivation effect on various bacteria, fungi, and viruses. However, because iodine has a very strong odor, when it is directly used for mucosal administration, it is more irritating to the mucosa, resulting in poor medication compliance of patients. Moreover, the solubility of iodine in water is relatively poor, and it is often necessary to deiodine with alcohol after clinically using iodine tincture to disinfect the skin, which also brings certain inconvenience to clinical application. [0003] Iodine is very easy to sublimate at normal temperat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K9/20A61K9/16A61K9/48A61K9/00A61P1/02A61P11/04
Inventor 常明申东民王莉芳梁敏
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap