Sinowilsonia henryi extract and its prepn process, composition and use

An extraction method and extract technology are applied in the application field of preparing medicines for treating hyperglycemia and obesity, and achieve the effects of reducing the area under the blood sugar curve, inhibiting the rise of blood sugar, and delaying digestion and absorption

Inactive Publication Date: 2006-11-08
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology prevents excessive accumulation of sugar inside body tissues by controlling how much it's getting taken up from food or drink before eating them for longer periods. It also reduces glycemia during fasting compared to regular diets without this treatment.

Problems solved by technology

Technologies aim towards developing novel medicines called alpha -gliptosis inhibitor(αG) compounds that could improve symptoms caused by various types of neurology conditions like Parkinsonism, Alzheimer’s Disease, Multiple Sclerosis, Autonomic Failures Type I/II Diabetsmimics Syndrome, Hyperprotinolemiectirception Neuron G protein Coupling Receptors involved in brain development and impulse conduction pathways associated with heart attacks and strokes. These technical problem addressed through researchers working together against different causes leading to discovery of newer therapies.

Method used

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  • Sinowilsonia henryi extract and its prepn process, composition and use
  • Sinowilsonia henryi extract and its prepn process, composition and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1. water extraction extract

[0044] Radix 100g, heat reflux with 500g of distilled water, extract three times (500g water / time), extract one hour at every turn, obtain water extract 15.5g after extracting liquid concentrating under reduced pressure. Dissolve 15.5 g of the extract in 100 ml of water, add ethanol to contain 70% alcohol (volume ratio), precipitate, filter, and concentrate the filtrate to dryness to obtain 13.6 g of a yellow paste.

[0045] Separation of the filtrate on a macroporous resin column:

[0046] 13.6 g of the filtrate was dissolved in 50 ml of water, added to a 100 g macroporous resin column (D-101), washed with distilled water until the effluent was colorless, and the distilled water eluate was concentrated to dryness to obtain 11 g of eluate.

[0047] The macroporous resin was then eluted with ethanol until the effluent was colorless, and the ethanol-eluted part was concentrated to obtain 2.2 g. The macroporous resin is washed wit...

Embodiment 2

[0050] Embodiment 2. water extraction extract

[0051] 1 kilogram of Radix Twig is extracted under reflux with 14 kilograms of distilled water, extracted three times (14 kilograms of water / time), and extracted for one hour each time, and the extract was concentrated under reduced pressure to obtain 155 g of water extract. 155 g of the extract was dissolved in 1550 ml of water, and ethanol was added to contain 70% alcohol (volume ratio), precipitated, filtered, and the filtrate was concentrated to dryness to obtain 136 g of a yellow paste.

[0052] Separation of the filtrate on a macroporous resin column:

[0053] 136 g of the filtrate was dissolved in 500 ml of water, added to a 1000 g macroporous resin column (D-101), washed with distilled water until the effluent was colorless, and the distilled water eluate was concentrated to dryness to obtain 110 g of eluate.

[0054] The macroporous resin was then eluted with ethanol until the effluent was colorless, and the ethanol elu...

Embodiment 3

[0057] Embodiment 3. Alcoholic extract

[0058] Add 1 kg of white tree bark, add 6 times the amount of 70% (volume ratio) ethanol, soak overnight or 4 hours, slowly heat to boiling, reflux for 1 hour, filter; repeat the whole process twice, combine the filtrate, concentrate under reduced pressure, temperature 60- 70°C, pressure 85-98KPa, when concentrated to completely free of ethanol, add 1 kg of water and continue to heat until boiling, after cooling, centrifuge to remove insoluble matter, and add a small amount of water to wash the insoluble matter three times, combine the filtrates, and reduce at a temperature of 60-70°C Concentrate under reduced pressure, and then dry under reduced pressure (temperature 70-80°C, pressure 85-98Kpa) to obtain 106g of extract.

[0059] Pharmacological experiment

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Abstract

The invention discloses an extract inhibiting α-glucosidase extracted from Radix Gingeri, a preparation method of the extract, a pharmaceutical composition containing the extract, and the use of the extract and the pharmaceutical composition as a medicine purposes, especially the application of preparing medicines for treating hyperglycemia and obesity.

Description

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Claims

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Application Information

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Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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