Unlock instant, AI-driven research and patent intelligence for your innovation.

Stable compositions comprising levosimendan and alginic acid

A levosimendan and composition technology, applied in the field of stable compositions containing levosimendan and alginic acid, can solve problems such as poor stability

Inactive Publication Date: 2001-06-06
ORION CORPORATION
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Levosimendan exhibits poor stability when mixed with conventional excipients and is prone to degradation under storage conditions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The following examples are intended to further illustrate the present invention, rather than limit the present invention. Example 1: Comparison of the stability of formulations according to the invention (1 and 2) and reference formulations (1-4) under storage conditions. Preparation 1 (hard gelatin capsule): Levosimendan 2mg Methocel K100LV 46mg alginic acid 23mg Avicel PH101 69.5mg stearic acid 1.5mg Preparation 2 (compressed tablet): Levosimendan: alginic acid 1:10 Reference preparation 1 (hard gelatin Capsules): levosimene 2mg Methocel K4M 35mg Avicel PH101 101.6mg stearic acid 1.4mg Reference preparation 2 (hard gelatin capsule): levosimene 2mg lactose 197mg magnesium stearate 1mg Reference preparation 3 (compressed tablet): levosimene Denier: lactose 1:100 Reference preparation 4 (compressed tablet): levosimendan: magnesium stearate 1:1

[0012] Formulation 1 consisting of a granule part and a powder part is prepared as follows: Methocel K100LV, alginic acid and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to pharmaceutical compositions of levosimendan comprising alginic acid for improving the stability of levosimendan in the compositions. Levosimendan is useful in the treatment of congestive heart failure.

Description

technical field [0001] The present invention relates to compounds containing levosimendan, namely [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazino]propane The (-) enantiomer of dinitrile as active ingredient, pharmaceutical composition, especially oral pharmaceutical composition, with improved stability. Levosimendan is used to treat congestive heart failure. Background technique [0002] Levosimendan, ie [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazinyl] is described in EP565546 B1 (-) Enantiomer of Malononitrile and Process for its Preparation. Levosimendan is effective in the treatment of heart failure and has significant calcium-dependent binding to troponin. Levosimendan is represented by Formula I: [0003] The hemodynamic effects of levosimendan are described by Sundberg, S. et al. in Am. J. Cardiol., 1995;75:1061-1066. Sandell, E.-P et al. described in "Journal of Cardiovascular Pharmacology" (J.C...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/28A61K9/48A61K31/50A61K31/501A61K47/36A61P9/04
CPCA61K31/50A61K9/205A61K47/36A61P9/00A61P9/04A61P9/10
Inventor I·拉尔玛M·哈朱拉
Owner ORION CORPORATION