Method for preparing polyurethane medical anti-infectious interventional catheter

An interventional catheter and anti-infection technology, applied in the direction of catheters, etc., can solve the problems of limited selection of antibacterial agents, damage and deformation of catheters, and limited coating thickness, and achieve the effects of convenient operation, high loading capacity and low cost.

Inactive Publication Date: 2007-03-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first two methods often involve the use of polar solvents, which lead to catheter damage and deformation and printing ink detachment, and are also limited by the thickness of the coating; while the latter method requires special and expensive equipment, and also has great limitations on the selection of antimicrobial agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 500 grams of composite antibacterial agent (inorganic silver-carried antibacterial agent and organic antibacterial agent triclosan are mixed in a mass ratio of 1:9) and 1500 grams of polyethylene-vinyl acetate (vinyl acetate content is 28%) are put into a vacuum oven Dry for 12 hours at an oven temperature of 60°C. Let cool to room temperature and remove. Mix the composite antibacterial agent and polyethylene-vinyl acetate evenly, add to the feed hopper of the twin-screw machine, and extrude to granulate. The prepared masterbatch was put into a vacuum drying oven (at a temperature of 60° C.) and dried for 24 hours. Get 140 grams of antibacterial pellets, mix evenly with 1860 grams of dried barium sulfate-doped polyurethane, add the hopper of a single-screw extruder, and extrude to obtain a catheter with anti-infection function.

Embodiment 2

[0028] Put 400 grams of compound antibacterial agent (ciprofloxacin and rifampicin mixed in a mass ratio of 1:2) and 1600 grams of barium sulfate-doped polyurethane into a vacuum oven for 12 hours and dry at a temperature of 80°C. Let cool to room temperature and remove. Mix the composite antibacterial agent with barium sulfate-doped polyurethane, then add 4 grams of antioxidant 1010, 3.2 grams of UV light stabilizer 770, 7 grams of zinc stearate and 7 grams of calcium stearate, and mix the raw materials evenly , into the feed hopper of the twin-screw machine, extruded and granulated. The prepared masterbatch was put into a vacuum drying oven (at a temperature of 80° C.) and dried for 24 hours. Get 40 grams of antibacterial masterbatch, mix evenly with 1960 grams of dried barium sulfate-doped polyurethane, add into the hopper of single-screw extrusion molding machine, extrude and form, and make the catheter with anti-infection function.

Embodiment 3

[0030] 700 grams of composite antibacterial agent (inorganic silver-carried antibacterial agent and minocycline are mixed in a mass ratio of 1:8) and 1300 grams of polyether polyurethane were put into a vacuum oven for drying for 12 hours, and the oven temperature was 70°C. Let cool to room temperature and remove. Then the compound antibacterial agent is mixed with polyether polyurethane, then add 4 grams of antioxidant 1010, 1.6 grams of UV stabilizer 770, 16 grams of zinc stearate and 16 grams of calcium stearate, after the raw materials are mixed uniformly , into the feed hopper of the twin-screw machine, extruded and granulated. The prepared masterbatch was put into a vacuum drying oven (at a temperature of 80° C.) and dried for 24 hours. Get 100 grams of antibacterial masterbatch, mix evenly with 1900 grams of dried barium sulfate-doped polyurethane, add into the hopper of a single-screw extrusion molding machine, extrude and form, and make a catheter with anti-infection...

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PUM

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Abstract

The invention relates to a polyurethane medical anti-infection insertion guide tube preparing method, preparing antimicrobial-containing antibacterial mother material to mix with the polyurethane raw material, and extruding to shape so as to obtain the guide tube, its antimicrobial loadage high and its antibacterial effect more permanent; its inner and outer walls has the same antibacterial effect; the technique is simple, the operation is convenient and the cost is low.

Description

technical field [0001] The invention relates to a method for preparing a medical anti-infection interventional catheter, in particular to a method for preparing a polyurethane medical anti-infection interventional catheter by using an antibacterial masterbatch. Background technique [0002] Medical interventional catheters have been widely used in clinical treatment. However, during the use of medical interventional catheters, bacteria often adsorb on the surface of the catheter and cause infection, which limits the use of the catheter. It is generally believed that the infection begins at the opening of the epidermis. After the bacteria undergo a dynamic reversible adsorption and irreversible adhesion process on the surface of the material, they attach and secrete a layer of biofilm on the surface of the material, which can protect the bacteria in the film from the host body. The immune mechanism and the influence of antibiotics can promote the furt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/16
Inventor 姜宏伟卢珣黄洪伟崔跃飞
Owner SOUTH CHINA UNIV OF TECH
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