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Miniature biochemical analyzer using dual-spectrum detection

A biochemical analyzer, dual-spectrum technology, applied in the field of photoelectric spectrum detection and spectrum biochemical analysis, can solve the problems of lack of calibration system baseline and automatic noise elimination, unsuitable for biological sample measurement and biochemical analysis, etc. Stable and portable effect

Inactive Publication Date: 2002-03-06
周向前 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lack of features to calibrate system baseline and automatic noise cancellation
Therefore, this system is not suitable for the measurement and biochemical analysis of biological samples

Method used

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  • Miniature biochemical analyzer using dual-spectrum detection
  • Miniature biochemical analyzer using dual-spectrum detection
  • Miniature biochemical analyzer using dual-spectrum detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The structure of Example 1 is as follows figure 1 Shown. The micro biochemical analyzer of this embodiment is composed of two integrated optical micro spectrometers with the same structure and performance. One is used to measure the sample, and the other is used to measure the reference comparison sample. It is also possible to measure a sample simultaneously with two micro-spectrometers. Through reference signal processing, real-time feedback control, self-calibration, error correction, and noise reduction functions can be performed.

[0040] figure 1 The medium adaptive adjustable light source 1 emits a broad-spectrum light beam, and reaches the beam splitter 4 through the focusing collimator lens 2 and the optical attenuator 3. The transmitted light beam enters the sample chamber 5 to be tested, and is absorbed, reflected and scattered by the sample. The light beam emitted from the sample chamber enters the optical fiber 7 through the condensing lens 6. The optical fi...

Embodiment 2

[0041] An improved embodiment 2 of the present invention, such as figure 2 Shown. This embodiment includes two independent micro-spectrometers, the structure of which is mainly that a beam splitter 101 and a beam splitter 102 are added to the basic optical path of the first embodiment. The micro-spectrometers 8 and 15 can respectively compare the measured sample 5 and the reference sample 12 at the same time, and the micro-spectrometers 8 and 15 can also perform continuous spectrum scanning measurement on the same sample 5 at the same time. Due to the use of array photoelectric scanning devices, spectral scanning and photoelectric signal conversion are performed at a very high frequency. For example: above 1KHz. The influence of environment and sample instability is very small, and the noise is very low.

[0042] The micro-spectrometer in the present invention is a continuous spectrum scan. According to the measured characteristic absorption data of any component of the sample, a...

Embodiment 3

[0047] Example 3 such as Figure 4 As shown in c, the optical attenuator is composed of a polarizer 48 and an analyzer 49 placed in a coaxial position. When the polarizer 48 and the analyzer 49 are relatively rotated around the axis 50 by the driving device, the transmitted light will be change.

[0048] The position of the optical attenuator 42, the rotation angle of the disc attenuator 45, and the relative rotation angle of the polarizer 48 and the analyzer 49 of the above three embodiments all correspond to the transmittance parameters and are controlled by the adaptive system. The displacement drive and rotation drive device are connected with the computer, and the computer sends out control signals to realize feedback control.

[0049] The embodiment structure and principle of the integrated optical micro-spectrometer of the present invention are as follows Figure 5 Shown. The structure is composed of an integrated optical dispersion grating 53 and an array photodetector 54....

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Abstract

A miniature biochemical analyzer using dual-spectrum detection is composed of the first optical channel consisting of adaptive regulatable light source, optical attenuator, the first specimen chamber, the first integrated spectrometer and the first A / D converter, the second optical channel consisting to the second specimen chamber, the second integrated spectrometer and the second A / D converter, and the computer data processing system. Its advantages include wide dynamic range and more functions of adaptive dynamic regulation, self scaling, and real-time error correction.

Description

Technical field [0001] The invention belongs to the technical field of photoelectric spectrum detection and spectrum biochemical analysis; in particular, it relates to the structural design of a spectrum detection biochemical analyzer. Background technique [0002] Ordinary biochemical analyzers and spectrophotometers similar to instruments have only one monochromator system, and some systems have two sets of monochromators, but the detector is shared by two channels and does not have the performance of a linear array detector. [0003] A dual spectrometer system (USP5,793,486) as a color sensor is used as a paper color measurement instrument. The system uses two spectrometers. One is aimed at the high reflection area (white area) of the paper, and the other is aimed at the high absorption area (black area) of the paper. Two spectrometers measure the full spectrum of the two regions at the same time. This system is suitable for online measurement of the color and color-related ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01J3/427G01N21/17
Inventor 周向前王佳
Owner 周向前
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