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Medicinal film for blood stanching of wound surface and its preparation method

A kind of technology of medicine film and wound surface, which is applied in the field of wound hemostatic sealing medicine film and its preparation, which can solve the problems of increased difficulty and complexity of drug preparation process, poor hemostatic and hydrophilic properties, and threats to the safety of medicines. Good hydrophilicity and rapid hemostasis effect, no toxic side effects, large degree of freedom

Inactive Publication Date: 2003-07-16
于美丽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its medicinal ingredients are mainly equestrian gliadin, bovine thrombin, and bovine aprotinin extracted from animals. Due to the spread of mad cow disease and other diseases and the entrainment of pathogenic bacteria and viruses in animals, it not only affects the production of drugs The extraction process increases the difficulty and complexity, and also poses a threat to the safety of the drug; in addition, the drug has poor hemostatic and hydrophilic properties in the body, so it has great application limitations, and it is not suitable for hemostatic sealing of surgical wounds. And the medicine cost is expensive, becomes the defective of prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0032] Soak 5kg of Bletilla striata powder with 30kg of normal temperature water for 6 hours, put it into a jacketed tank to heat up, stir for 4 hours at 50°C, and extract the polysaccharide liquid; filter the dregs and add 30kg of water and heat up to Soak while stirring at 60°C, and filter after 3 hours; add 15kg of water to the filtered medicinal residues and raise the temperature to 70°C, soak while stirring for 3 hours, filter and discard the medicinal residues. The medicinal liquid extracted three times was evenly mixed, and concentrated under reduced pressure at a liquid temperature of 79° C. to obtain a 500 kg concentrated medicinal liquid. Put it into a centrifuge at 4000 rpm at a liquid temperature of 16°C for 30 minutes to separate, discard the precipitate and retain the purified and concentrated medicinal liquid. The medicinal solution is injected into 96% medical alcohol, flocculent precipitates appear in the solution, and the precipitated drug is filtered out aft...

example 2

[0034] Mix 4.0kg of Bletilla striata powder and 1.0kg of Burnet urchin powder, soak in 32kg of normal temperature water for 6 hours, put it into a jacketed tank to raise the temperature, stir at 51°C for 4 hours, and extract the polysaccharide liquid; Add 32kg of water to the dregs of the medicine, heat up to 61°C and soak while stirring, and filter after 3 hours; add 16kg of water to the filtered dregs, heat up to 71°C and soak while stirring for 3 hours, filter and discard the dregs. The medicinal liquid extracted three times was evenly mixed, and concentrated under reduced pressure at a liquid temperature of 79° C. to obtain a 500 kg concentrated medicinal liquid. Add 0.112kg of donkey-hide gelatin, place it in a centrifuge at 4000 rpm for 30 minutes at a liquid temperature of 17°C and separate it for 30 minutes, discard the precipitate and keep the purified and concentrated medicinal solution. The medicinal solution is injected into 96% medical alcohol, flocculent precipit...

example 3

[0036] Mix 4.75kg of Bletilla striata powder and 0.25kg of Burnet eucalyptus powder, soak in 31kg of normal temperature water for 6 hours, put it in a jacketed tank to raise the temperature, stir at 52°C for 4 hours, and extract the polysaccharide liquid; Add 31kg of water to the dregs of the medicine, heat up to 62°C and soak while stirring, and filter after 3 hours; add 15.5kg of water to the filtered dregs of the medicine, heat up to 72°C and soak for 3 hours while stirring, filter and discard the dregs of the medicine. The medicinal liquid extracted three times is uniformly mixed, and concentrated under reduced pressure at a liquid temperature of 80° C. to obtain a 500 kg concentrated medicinal liquid. Add 0.237kg of donkey-hide gelatin, place it in a centrifuge at 4000 rpm for 30 minutes at a liquid temperature of 18°C, and discard the precipitate to obtain a purified and concentrated medicinal solution. The medicinal solution is injected into 96% medical alcohol, floccul...

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Abstract

A styptic medicine in the form of film for hemostasis of wound is prepared from the medical plant containing polyose (90-95 wt.%) through pulverizing the plant, immersing in water and filtering threetimes, mixing, then concentrating, centrifugal separation, adding medical alcohol, deposition, filtering, immersing the deposit in medical alcohol, filtering, dripdrying to obtain particles, dissolving in distilled water, ultralow-temp. (-106- -108 deg.C) free-drying to obtain paste, and coating to obtain the medicated film.

Description

technical field [0001] The invention relates to a hemostatic agent, in particular to a wound hemostatic sealing film and a preparation method thereof. Background technique [0002] At present, a lot of effective work has been done on absorbable local hemostatic agents, especially wound hemostatic sealants for large-scale resection of various solid organs. For example: Tachocomd absorbable wound hemostatic material developed by Hafslund Nycomed Pharmaceutical Company in Linz, Austria, has been widely used in clinical practice. However, its medicinal ingredients are mainly equestrian gliadin, bovine thrombin, and bovine aprotinin extracted from animals. Due to the spread of mad cow disease and other diseases and the entrainment of pathogenic bacteria and viruses in animals, it not only affects the production of drugs The extraction process increases the difficulty and complexity, and also poses a threat to the safety of the drug; in addition, the drug has poor hemostatic and ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61P7/04
Inventor 于美丽
Owner 于美丽
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