Method of treating peripheral vascular diseases, peripheral neuropathies, and automatic neuropathies

A technology for peripheral vascular disease and neuropathy, applied in cardiovascular system diseases, skin diseases, sensory diseases, etc., can solve the problems of unreported interest or concern of cGMPPDE5 inhibitors

Inactive Publication Date: 2003-09-03
PFIZER INC
View PDF13 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no interest or concern has been reported regarding c

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] Patient No. 1 was an insulin-dependent diabetic who had suffered from erectile dysfunction and subsequently suffered from a diabetic foot ulcer. During the treatment of erectile dysfunction, healed foot ulcers were noted. This foot ulcer started about 2 years ago and the patient has had vascular studies, seen a vascular doctor, a podiatrist, and at best and only minimally effective in a trauma care clinic. He was also hospitalized for about 1 month on IV antibiotics, etc., and there was a very real threat that the patient would need amputation below the knee. Ulcers sometimes appear to heal, but only return to their pre-treated size and depth. Once sildenafil was started for his erectile dysfunction, a reduction in size of the ulcer was noted and the patient was instructed to start taking 50 mg of sildenafil once a day. The diabetic foot ulcer thus completely resolved within one month, and the patient continued the treatment for the next 2 years without recurrence.

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a method of treating a patient suffering from peripheral vascular disease, peripheral neuropathies, or autonomic neuropathies by administering a cGMP PDE5 inhibitor such as sildenafil. The method is particularly applicable to patients suffering from diabetic foot ulcers, Raynaud's Phenomenon, CREST Syndrome, erythromatosis, rheumatoid diseases, diabetic retinopathies and onychiomycosis. According to the present invention, a cGMP PDE5 inhibitor may be administered as a prophylactic to patients predisposed to develop a peripheral vascular disease, peripheral neuropathy or autonomic neuropathy.

Description

[0001] Cross-Referenced Related Applications [0002] This application claims priority to U.S. Provisional Application No. 60 / 215,065 (filed June 30, 2000) and U.S. Provisional Application No. 60 / 219,029 (filed July 18, 2000), both entitled "Treatment of Diabetic Ulcers" method", the contents of which are hereby incorporated by reference in their entirety. field of invention [0003] The present invention relates to 3', 5'-cyclic guanosine monophosphate type V (cGMP PDE5) inhibitors (including the compound sildenafil) in diseases related to peripheral vascular disease, peripheral neuropathy, autonomic neuropathy, especially related to diabetes Use in the treatment of disease. Background of the invention [0004] The diseases associated with peripheral vascular disease and autonomic neuropathy are diverse but the chronic pathology is consistent and difficult to cure. Many of these diseases are associated with diabetes. Although it is not well known whether other such disea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/495C07D487/04A61K31/519A61K45/00A61P9/00A61P9/08A61P17/02A61P25/00A61P25/02A61P27/02A61P29/00A61P31/10
CPCA61K31/495A61P17/02A61P25/00A61P25/02A61P27/02A61P29/00A61P31/10A61P9/00A61P9/08
Inventor R·E·伍德
Owner PFIZER INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap