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Aromatic turmeric oil extracts and its preparing process and medicinal composition containing the same

A technology of zedoary oil and extract, which is applied to the effective part of traditional Chinese medicine and its preparation field, and can solve problems such as poor stability, strong irritation, and complex ingredients

Inactive Publication Date: 2004-12-29
李绍平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the shortcomings of zedoary oil, such as complex components, poor stability, and strong irritation, and to prepare a zedoary oil extract with strong action, small side effects, and good stability, that is, a composition composed of active components of zedoary oil , and use this component as an active ingredient, mix it with a pharmaceutically acceptable carrier, and prepare various preparations that can treat viral diseases, cardiovascular and cerebrovascular diseases, and tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 100 g of zedoary oil, mix well with 300 g of silica gel for column chromatography, pack the column, wash with 2000 ml of petroleum ether, and then elute with 2000 ml of ethyl acetate, collect the ethyl acetate part, and recover the ethyl acetate under vacuum at 60 ° C to obtain brown The yellow oil is the active component of zedoary oil.

[0018] It is detected by GC-MS, which is a conventional method for detecting volatile components, and does not contain 6-methylenemethylene-4,5,6,7-tetrahydro-3,6-dimethyl-5-isopropene with poor stability base-trans-benzofuran component. TLC (silica gel chromatography developer is: petroleum ether-ethyl acetate=9:1) analysis shows four brownish-red main spots, which are detected by GC-MS and compared with reference substances. The contents of curdione and curcumol are 30-60%: 15-40%: 1-15%: 1-20% by weight.

Embodiment 2

[0020] Take 10 g of the zedoary oil extract of the present invention and 90 g of vegetable oil, stir and mix, and filter through a 100-mesh sieve to make a medicinal solution. The above medicinal solution and capsule material (the ratio of glycerin: gelatin: water by weight is 1:3:3 parts) were routinely compressed on a soft capsule machine to form 1000 soft capsules containing the active component of zedoary oil. The recommended dosage for children is 1-3 capsules / day.

Embodiment 3

[0022] Get 100g of the curcuma oil extract of the present invention, 200g of vegetable oil, stir, mix, filter through 100 mesh sieves, make medicinal liquid. The above medicinal solution and capsule material (the ratio of glycerin: gelatin: water by weight is 1:3:3 parts) were routinely compressed on a soft capsule machine to form 1000 soft capsules containing the active component of zedoary oil. The recommended dosage is 1-3 capsules / day.

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Abstract

The zedoary extractive is prepared with zedoary oil as material and through chromatography with silica gel column, and contains curdione 30-60 wt%, elemenone 15-40 wt%, neo-curdione 1-15 wt%, curcumenol1-20 wt% and no instable benzofuran derivative. The zedoary extractive has high effect, less side effect and high stability, and may be mixed with different medicine carrier to prepare various medicine preparations, such as capsule and injection, for treating viral diseases, cardiac and cerebral vascular diseases and tumor.

Description

technical field [0001] The present invention belongs to the effective part of traditional Chinese medicine and its preparation method, specifically Chinese medicine zedoary oil extract, its preparation method and a pharmaceutical composition containing the zedoary oil extract Background technique [0002] Currently clinically used antiviral drugs include: anti-respiratory virus drugs ribavirin (RBV), amantadine, and polymyocytes; anti-herpes virus drugs acyclovir (ACV), ganciclovir (GCV), Sodium foscarnet; non-specific antiviral drug interferon, etc. Among them, RBV is better for RSV infection, but long-term high-dose application can cause reversible anemia, WBC decline, abnormal liver function and gastrointestinal adverse reactions; amantadine is only effective for influenza virus type A; polymyocytes can inhibit viral RNA It has the ability to induce interferon and is mainly used for the prevention and treatment of acute respiratory tract infection; ACV is better against ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/48A61K31/12A61P9/00A61P31/12A61P35/00
Inventor 李绍平
Owner 李绍平
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