Effective cowberry part for treating respiratory tract disease and its prepn process

An effective part, the technology of arbutin, applied to the effective part of lingonberry for treating respiratory diseases and its preparation field

Inactive Publication Date: 2005-04-27
林发 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of medical science, there are reports on the chemical components and pharmacological experiments of bilberry, but there are no reports at home and abroad on the treatment of acute and chronic infectious diseases of the respiratory system by the stems and leaves of bilberry.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0013] Preparation method of the present invention, it comprises the following steps:

[0014] a) Weigh the crude drug bilberry, take the coarse powder of the medicinal material, and carry out reflux extraction with 70-95% ethanol, recover the ethanol from the extract, add water to precipitate to remove chlorophyll, filter, and concentrate under reduced pressure to an extract with a relative density of 1.35.

[0015] b) Take the above-mentioned extract and put it on a macroporous resin column, wash it with 0.1-4.5 times the column volume of water, then elute with 2-12 times the column volume of 10-70% ethanol solution, recover the solvent under reduced pressure until dry, and store at 45-50°C The dried extract is used to make the active ingredient of the medicine of the present invention.

[0016] Said wherein the extract prepared in step b) is mixed with common capsule excipients, granulated, and packed into capsules.

[0017] The effective part extracted from the bilberry c...

Embodiment 1

[0019] The preparation of medicine blueberry capsule of the present invention

[0020] a) Weigh 30 g of the crude drug Vaccinium bilberry, take the coarse powder of the medicinal material and carry out reflux extraction with 80-95% ethanol, recover the ethanol from the extract, add water to precipitate to remove chlorophyll, filter, and concentrate under reduced pressure to an extract with a relative density of 1.35.

[0021] b) Take the above extract and put it on a macroporous resin column, wash it with 1-2 times the column volume of water, then elute with 6-8 times the column volume of 20-30% ethanol solution, recover the solvent under reduced pressure until dry, and store at 45-50°C Dry the extract.

[0022] c) The extract is pulverized, mixed with appropriate auxiliary materials, and packed into hard gelatin capsules.

Embodiment 2

[0024] The preparation of medicine bilberry gum granule of the present invention

[0025] a) Weigh 30 g of the crude drug Vaccinium bilberry, take the coarse powder of the medicinal material, and use 70-95% ethanol to carry out reflux extraction, recover the ethanol from the extract, add water to precipitate to remove chlorophyll, filter, and concentrate under reduced pressure to an extract with a relative density of 1.35.

[0026] b) Take the above extract and put it on a macroporous resin column, wash it with 1-2 times the column volume of water, then elute with 6-8 times the column volume of 20-50% ethanol solution, recover the solvent under reduced pressure until dry, and store at 45-50°C Dry the extract.

[0027] c) crush the extract, add ethanol as a binder, add dextrin as a filler, and press into granules.

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PUM

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Abstract

The effective cowberry part for treating acute and chronic respiratory tract infection consists of mainly phenol and glycoside components with arbutin as main component and flavones, and may be prepared into different orally taken preparation forms. The effective cowberry part has the functions of resisting inflammation, resisting virus, relieving cough, eliminating phlegm, relieving asthma, etc. and thus has fast and high curative rate in treating acute and chronic respiratory tract infection diseases.

Description

Technical field [0001] The invention relates to an effective part for treating acute and chronic respiratory infectious diseases and a preparation method thereof. Background technique [0002] Vaccinium Vaccinium Vitis-idaea L. is the leaf and fruit of Rhododendronaceae Vaccinium Vitis-idaea L. Bilberries are mainly distributed in Northern Europe, North America, Russia, and Daxing'an Mountains in Heilongjiang Province, Inner Mongolia, Xinjiang and other regions. The chemical composition contained in bilberry is complex, and the literature reports that bilberry contains natural active ingredients and mainly includes three categories: flavonoids, phenols, and tannins. Japanese scholar Harukiti Nakamura isolated isoquercetin, Janina Kaminska isolated flavonoids such as avicularin, rutin, quercetin-3-D-glucose-L-rhamnoside, etc. Former Soviet scholar Shyakina G.P isolated hyperoside (hyperoside); British scholar G.Britton isolated 2-O-caffeoyl arbutin; Base arbutin etc. Acut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/00A61P31/00C07H1/08
Inventor 王喜军林发陈曦吴修红
Owner 林发
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